Article (Scientific journals)
METABOLIC CHANGES IN THE MIGRAINE BRAIN IN RELATION TO AGEING AND DISEASE LOAD
D'Ostilio, Kevin; Lisicki Martinez, Marco; NONIS, Romain et al.
2016In Cephalalgia, 36 (1S), p. 59
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Abstract :
[en] Introduction: Migraine prevalence tends to decrease with advancing age. Morphological and functional brain changes occuring in migraine could be secondary to repeated attacks and/or to abnormal sensory processing. In normal ageing, brain modifications could traduce a progressive refinement to cope with the environment, associated with a reduction in the complexity of brain connections. We hypothesized that metabolism in various brain regions might be differentially modified by age in migraine patients. Materials and methods: Forty-one subjects underwent a FDG-PET scan: 21 patients with interictal episodic migraine without aura (MO, age range: 20–63 years, 5M) and 20 healthy controls (HV, 21–59 years, 5 M). Results: In MO vs. HV, the overall FDG uptake was reduced in the left visual cortex, left medial frontal gyrus and bilaterally in the insula, somatosensory and motor cortices. Metabolisms of the posterior thalamus, brainstem including the periaqueductal gray (PAG), visual cortex, and (para)hippocampus, strongly increased with age in MO patients but not in HV. Disease duration positively correlated with PAG, (para)hippocampus and rostral anterior cingulate cortex (rACC) metabolisms in MO. Conclusion: Migraine patients, compared to HV, have a decreased resting metabolism in several areas belonging to the ‘‘pain/salience matrix’’, which is in line with previous neuroimaging studies. Metabolism of the rACC is specifically related to disease load whereas metabolism of other sensory processing regions is more affected by age. Whether these functional changes are due to repeated stereotyped attack-related stimulations and to a learning process with complexity reduction of neuronal connections and/or compensatory age-related hyperactivity, remains to be demonstrated
Disciplines :
Neurology
Author, co-author :
D'Ostilio, Kevin ;  Université de Liège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Lisicki Martinez, Marco ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
NONIS, Romain ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'urologie
SCHOENEN, Jean  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie (CHR)
MAGIS, Delphine ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie (CHR)
Language :
English
Title :
METABOLIC CHANGES IN THE MIGRAINE BRAIN IN RELATION TO AGEING AND DISEASE LOAD
Publication date :
2016
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
Blackwell Science, Osney Mead Oxford, United Kingdom
Volume :
36
Issue :
1S
Pages :
59
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 602633 - EUROHEADPAIN - Mechanisms and Treatment of Migraine and its Chronification
Funders :
CE - Commission Européenne [BE]
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since 21 October 2016

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