Article (Scientific journals)
TRANSCUTANEOUS OCCIPITAL NERVE STIMULATION AND TRANSCRANIAL DIRECT CURRENT STIMULATION IN CHRONIC MIGRAINE: A PILOT COMPARISON OF THERAPEUTIC AND ELECTROPHYSIOLOGICAL EFFECTS
MAGIS, Delphine; D'Ostilio, Kevin; Baschi et al.
2016In Cephalalgia, 36 (1S), p. 31
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Abstract :
[en] Background: Management of chronic migraine (CM) is often challenging. There is a need for more effective and better-tolerated preventive therapies. Among non-invasive neurostimulation procedures, transcutaneous occipital nerve stimulation (tONS) would act via central pain modulation, while transcranial direct current stimulation (tDCS) would modify cortical excitability that is abnormal in CM. Objectives: In this pilot trial we compared the clinical effects of tDCS and tONS in refractory CM and their ability to modify nociception and cortical responsiveness. Methods: Forty-three CM patients (17 with history of drug overuse) applied either 2mA tDCS during 2 months (N¼20, cathode over visual cortex, anode over left DLPFC), or tONS during 3 months (N¼23, Cefaly Kit ArnoldTM), both in daily 20 min-sessions. Visual evoked potentials (VEP), nociceptive blink reflexes (nBR) and quantitative sensory testing were recorded before and after treatment. Results: During the last stimulation month, total headache days decreased in both groups ( 16.4% for tDCS, 17% for tONS, p<0.05). Migraine days were reduced by 21.4% (p¼0.06) and 22% (p<0.05) respectively, while 30% responder rates were 47% and 42%. Medication intake was significantly reduced after tONS ( 43%). There was no significant change of nBR in either group. VEP habituation reversed to an episodic migraine pattern, i.e. a deficit, after tONS but not after tDCS. Conclusion: tONS and inhibitory tDCS of the visual cortex are interesting non-invasive options for the treatment of CM, but these results have to be confirmed in a randomized controlled trial. tONS was able to induce recordable changes in visual cortex responsiveness
Disciplines :
Neurology
Author, co-author :
MAGIS, Delphine ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie (CHR)
D'Ostilio, Kevin ;  Université de Liège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Baschi
Cosseddu, Anna
Lisicki Martinez, Marco ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
NONIS, Romain ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'urologie
Simona, Sava
SCHOENEN, Jean  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie (CHR)
Language :
English
Title :
TRANSCUTANEOUS OCCIPITAL NERVE STIMULATION AND TRANSCRANIAL DIRECT CURRENT STIMULATION IN CHRONIC MIGRAINE: A PILOT COMPARISON OF THERAPEUTIC AND ELECTROPHYSIOLOGICAL EFFECTS
Publication date :
2016
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
Blackwell Science, Osney Mead Oxford, United Kingdom
Volume :
36
Issue :
1S
Pages :
31
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 602633 - EUROHEADPAIN - Mechanisms and Treatment of Migraine and its Chronification
Funders :
CE - Commission Européenne [BE]
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