Article (Scientific journals)
How the reference values for serum parathyroid hormone concentration are (or should be) established?
Souberbielle, Jean-Claude; Brazier, F.; Piketty, M.-L. et al.
2017In Journal of Endocrinological Investigation, 40 (3), p. 241-256
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Keywords :
Chronic kidney disease; Parathyroid hormone (PTH); Primary hyperparathyroidism; Reference values; Vitamin D
Abstract :
[en] Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria for this population can be defined as any situation possibly inducing an increase or a decrease in PTH concentration. As recommended in the recent guidelines on the diagnosis and management of asymptomatic primary hyperparathyroidism, PTH reference values should be established in vitamin D-replete subjects with a normal renal function with possible stratification according to various factors such as age, gender, menopausal status, body mass index, and race. A consensus about analytical/pre-analytical aspects of PTH measurement is also needed with special emphasis on the nature of the sample (plasma or serum), the time and the fasting/non-fasting status of the blood sample. Our opinion is that blood sample for PTH measurement should be obtained in the morning after an overnight fast. Furthermore, despite longer stability of the PTH molecule in EDTA plasma, we prefer serum as it allows to measure calcium, a prerequisite for a correct interpretation of a PTH concentration, on the same sample. Once a consensus is reached, we believe an important international multicentre work should be performed to recruit a very extensive reference population of apparently healthy vitamin D-replete subjects with a normal renal function in order to establish the PTH normative data. Due to the huge inter-method variability in PTH measurement, a sufficient quantity of blood sample should be obtained to allow measurement with as many PTH kits as possible.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Souberbielle, Jean-Claude
Brazier, F.
Piketty, M.-L.
Cormier, C.
Minisola, S.
Cavalier, Etienne  ;  Université de Liège > Département de pharmacie > Chimie médicale
Language :
English
Title :
How the reference values for serum parathyroid hormone concentration are (or should be) established?
Publication date :
March 2017
Journal title :
Journal of Endocrinological Investigation
ISSN :
0391-4097
eISSN :
1720-8386
Publisher :
Editrice Kurtis srl, Italy
Volume :
40
Issue :
3
Pages :
241-256
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 October 2016

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