Article (Scientific journals)
An endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys sp.) from Indonesia
Alfano, niccolo; Michaux, Johan; Fabre, Pierre-Henri et al.
2016In Journal of Virology
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Abstract :
[en] Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated froma cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or moreintermediate as yet unknown hosts. A highly similar virus to GALV has been identified in anAustralian rodent (Melomys burtoni) after extensive screening of Australian wildlife. GALV-likeviruses have also been discovered in several Southeast Asian species although screening has not beenextensive and viruses discovered to date are only distantly related to GALV. We therefore screened 26Southeast Asian rodent species for KoRV- and GALV-like sequences, using hybridization capture andhigh-throughput sequencing, in the attempt to identify potential GALV and KoRV hosts. Only onespecies, an undescribed species of Melomys from Indonesia, was positive yielding an endogenousprovirus very closely related to a strain of GALV. The sequence of the critical receptor domain forGALV infection in the Indonesian Melomys sp. was consistent with the susceptibility of the species toGALV infection. The discovery of a GALV in a second Melomys species provides further evidencethat Melomys may play a role in the spread of GALV-like viruses, especially since the genus is foundin Indonesia, Papua New Guinea and Australia, connecting the home ranges of koalas and gibbons
Disciplines :
Zoology
Author, co-author :
Alfano, niccolo
Michaux, Johan  ;  Université de Liège > Département des sciences de la vie > Génétique et physiologie des microalgues
Fabre, Pierre-Henri
Morand, Serge
Aplin, Ken
Tsangaras, Kyriakos
Lober, Ulrike
Fitriana, Yuli
Semiadi, Gono
Ishida, Yasuko
Helgen, Kristofer
Roca, Alfred
Eiden, Maribeth
Greenwood, Alex
More authors (4 more) Less
Language :
English
Title :
An endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys sp.) from Indonesia
Publication date :
2016
Journal title :
Journal of Virology
ISSN :
0022-538X
eISSN :
1098-5514
Publisher :
American Society for Microbiology (ASM), Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 October 2016

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