Article (Scientific journals)
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
DELANAYE, Pierre; Melson, Toralf; Ebert, Natalie et al.
2016In NDT Plus
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Keywords :
glomerular filtration rate; iohexol
Abstract :
[en] 2 | P. Delanaye et al. Abstract A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrowtherapeutic index. Abnormally elevatedGFRor hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies duetoGFRestimation with different equations. Usingmeasured GFR, successfullyaccomplished in large epidemiological studies, is the onlyway to study the potential link between decreased renal functionand cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research.
Disciplines :
Laboratory medicine & medical technology
Urology & nephrology
Author, co-author :
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
Melson, Toralf
Ebert, Natalie
Bäck, Sten-Erik
Mariat, Christophe
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de chimie clinique
Björk, Jonas
Christensson, Anders
Nyman, Ulf
Porrini
Remuzzi, Giuseppe
Ruggenenti, Piero
Schaeffner, Elke
Soveri, Inga
Sterner, Gunnar
Odvar Eriksen, Bjorn
Gaspari, Flavio
More authors (7 more) Less
Language :
English
Title :
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
Publication date :
October 2016
Journal title :
NDT Plus
ISSN :
1753-0784
eISSN :
1753-0792
Publisher :
Oxford University Press, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 October 2016

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