[en] Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients.
AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients.
AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC.
Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients.
Disciplines :
Neurosciences & behavior
Author, co-author :
Genon, Sarah ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Simon, Jessica ; Université de Liège > Département de Psychologie > Psychologie quantitative
Bahri, Mohamed Ali ; Université de Liège > Centre de Recherches du Cyclotron > Centre de Recherches du Cyclotron
Collette, Fabienne ; Université de Liège > Département de Psychologie > Neuropsychologie
Souchay, Céline
Jaspar, Mathieu ; Université de Liège > Département de Psychologie > Ergonomie et intervention au travail
Bastin, Christine ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
SALMON, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie
Language :
English
Title :
Relating pessimistic memory predictions to Alzheimer’s disease brain structure
Publication date :
December 2016
Journal title :
Cortex: A Journal Devoted to the Study of the Nervous System and Behavior
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