Doctoral thesis (Dissertations and theses)
On the GMP production of [18]FUCB-H : Imaging neurotransmission
Warnier, Corentin
2016
 

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Keywords :
fluorine-18; UCB-H; PET; iodonium; 18F
Abstract :
[en] We herein describe the straightforward synthesis of a stable pyridyl(aryl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radi-osynthesis of [18F]UCB-H, a PET tracer for the imaging of Synaptic Vesicle glycoprotein 2A (SV2A). Over the course of one year, 40 automated productions provided 34±2% of injectable [18F]UCB-H from up to 7.7 Ci of [18F]fluoride in 50 minutes (uncorrected radiochemical yield. Specific Activity = 22±5 Ci/µmol). The successful implementation of our synthetic strategy within routine, high-activity and cGMP productions attests to its practicality and reliability for the production of large doses of [18F]UCB-H. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts in the cGMP 18F-PET tracer manufacturing industry and their ability to fulfill practical and regulatory requirements in that field.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Warnier, Corentin ;  Université de Liège > Centre de recherches du cyclotron
Language :
English
Title :
On the GMP production of [18]FUCB-H : Imaging neurotransmission
Defense date :
26 September 2016
Number of pages :
189
Institution :
ULiège - Université de Liège
Degree :
Docteur en Sciences
Promotor :
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences)
President :
Damblon, Christian ;  Université de Liège - ULiège > Molecular Systems (MolSys)
Secretary :
Lemaire, Christian ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Radiochemistry
Jury member :
Gouverneur, Véronique
Valade, Anne
Monbaliu, Jean-Christophe  ;  Université de Liège - ULiège > Département de chimie (sciences) > Center for Integrated Technology and Organic Synthesis
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
Région wallonne [BE]
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since 20 September 2016

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