25-hydroxyvitamin D3; absorption; fasting; high fat
Abstract :
[en] Vitamin D(3) is known to be liposoluble and its release could be a factor limiting the rate of absorption. It was presumed that the presence of fat could favor absorption of vitamin D(3). However, as bioavailability is related not only to the active molecules but also to the formulations and excipients used, the optimization of the pharmaceutical form of vitamin D(3) is also important. The objective of this study was to evaluate if there is a food effect on absorption when a high dose of vitamin D(3) is completely solubilized in an oily solution. In the present cross-over study, 88 subjects were randomized and received a single dose of 50,000 IU of vitamin D(3) in fasting state or with a standardized high-fat breakfast. Assessment of serum concentrations of 25 hydroxyvitamin D(3) (25(OH)D(3)) was performed three, five, seven, 14, 30 and 60 days after supplementation. In fed and fast conditions, the 25(OH)D(3) serum concentrations were significantly higher than the baseline value three days after administration and remained significantly higher during the first month. No significant difference between fasting vs. fed conditions was observed. It is therefore concluded that the vitamin D(3) absorption from an oily solution was not influenced by the presence or absence of a meal.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Cavalier, Etienne ; Université de Liège > Département de pharmacie > Chimie médicale
Jandrain, Bernard
Coffiner, Monte
Da Silva, Stephanie
De Niet, Sophie
Vanderbist, Francis
Souberbielle, Jean-Claude
Language :
English
Title :
A Randomised, Cross-Over Study to Estimate the Influence of Food on the 25-Hydroxyvitamin D(3) Serum Level after Vitamin D(3) Supplementation.
Publication date :
May 2016
Journal title :
Nutrients
ISSN :
2072-6643
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
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