Abstract :
[en] Purpose of review
This article reviews recently published evidence for common pathways explaining bone and muscle wasting
in normal ageing and pathological conditions.
Recent findings
Numerous studies support the concept of a bone–muscle unit, where constant cross-talking between the two
tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and
osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells.
Summary
New chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed
by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the
communication between the two tissues.
Scopus citations®
without self-citations
145