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Modulating effect of COMT genotype on brain areas underlying cognitive control processes
Collette, Fabienne; Jaspar, Mathieu
2016Joint Meeting of the British Neuropsychological Society with la Société de Neuropsychologie de Langue Française
 

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Keywords :
cognitive control; fMRI; genetic
Abstract :
[en] Catechol-O-methyltransferase (COMT) is an important enzyme which degrades catecholamines, such dopamine, notably in the prefrontal cortex. A large number of studies reported an effect on executive functioning of COMT genotype, each genotype being associated with a different COMT enzymatic activity. In this talk, I will present some of our studies that explored the neural substrates of inhibitory processes according to COMT genotype. These studies showed that COMT genotype modulates the brain-level implementation of proactive and reactive inhibitory control processes. We will discuss how individual differences related to DA-mediated signaling can differently influence inhibition in function of the form of cognitive control required by the task, but also regarding the specific inhibitory mechanism induced by the task.
Disciplines :
Neurosciences & behavior
Author, co-author :
Collette, Fabienne  ;  Université de Liège > Département de Psychologie > Neuropsychologie
Jaspar, Mathieu ;  Université de Liège > Département de Psychologie > Ergonomie et intervention au travail
Language :
English
Title :
Modulating effect of COMT genotype on brain areas underlying cognitive control processes
Publication date :
18 March 2016
Event name :
Joint Meeting of the British Neuropsychological Society with la Société de Neuropsychologie de Langue Française
Event place :
Londres, United Kingdom
Event date :
17-18 mars 2016
By request :
Yes
Audience :
International
Available on ORBi :
since 31 August 2016

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