Replacement of Glycoprotein B in Alcelaphine Herpesvirus 1 by Its Ovine Herpesvirus 2 Homolog : Implications in Vaccine Development for Sheep-Associated Malignant Catarrhal Fever.
Cunha, Cristina W.; Taus, Naomi S.; Dewals, Benjamin Get al.
[en] Vaccine development is a top priority in malignant catarrhal fever (MCF) research. In the case of sheep-associated MCF (SA-MCF) caused by ovine herpesvirus 2 (OvHV-2), progress toward this objective has been hindered by the absence of methods to attenuate or modify the virus, since it cannot be propagated in vitro. As an alternative for vaccine development, in this study, we tested the hypothesis that one of the SA-MCF vaccine candidate targets, OvHV-2 glycoprotein B (gB), could be expressed by a nonpathogenic alcelaphine herpesvirus 1 (AlHV-1) and then evaluated the potential of the AlHV-1/OvHV-2 chimera to be used as a vaccine and a diagnostic tool. The construction and characterization of an AlHV-1/OvHV-2 chimeric virus that is nonpathogenic and expresses an OvHV-2 vaccine target are significant steps toward the development of an SA-MCF vaccine and also provide a valuable means to study OvHV-2 biology.
Replacement of Glycoprotein B in Alcelaphine Herpesvirus 1 by Its Ovine Herpesvirus 2 Homolog : Implications in Vaccine Development for Sheep-Associated Malignant Catarrhal Fever.
Publication date :
03 August 2016
Journal title :
mSphere
eISSN :
2379-5042
Publisher :
American Society for Microbiology, Washington, United States - Washington
Davison AJ, Eberle R, Ehlers B, Hayward GS, McGeoch DJ, Minson AC, Pellett PE, Roizman B, Studdert MJ, Thiry E. 2009. The order Herpesvirales. Arch Virol 154:171-177. http://dx.doi.org/10.1007/s00705-008-0278-4
O'Toole D, Li H. 2014. The pathology of malignant catarrhal fever, with an emphasis on ovine herpesvirus 2. Vet Pathol 51:437-452. http:// dx.doi.org/10.1177/0300985813520435
Li H, Cunha CW, Taus NS, Knowles DP. 2014. Malignant catarrhal fever: inching toward understanding. Annu Rev Anim Biosci 2:209-233. http:// dx.doi.org/10.1146/annurev-animal-022513-114156
Dry I, Haig DM, Inglis NF, Imrie L, Stewart JP, Russell GC. 2008. Proteomic analysis of pathogenic and attenuated alcelaphine herpesvirus 1 J Virol 82:5390-5397. http://dx.doi.org/10.1128/JVI.00094-08
Haig DM, Grant D, Deane D, Campbell I, Thomson J, Jepson C, Buxton D, Russell GC. 2008. An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever. Vaccine 26:4461-4468. http://dx.doi.org/10.1016/ j.vaccine.2008.06.056
Russell GC, Benavides J, Grant D, Todd H, Deane D, Percival A, Thomson J, Connelly M, Haig DM. 2012. Duration of protective immunity and antibody responses in cattle immunised against alcelaphine herpesvirus-1-induced malignant catarrhal fever. Vet Res 43:51. http:// dx.doi.org/10.1186/1297-9716-43-51
Taus NS, Cunha CW, Marquard J, O'Toole D, Li H. 2015. Crossreactivity of neutralizing antibodies among malignant catarrhal fever viruses. PLoS One 10:e0145073. http://dx.doi.org/10.1371/ journal.pone.0145073
Palmeira L, Sorel O, Van Campe W, Boudry C, Roels S, Myster F, Reschner A, Coulie PG, Kerkhofs P, Vanderplasschen A, Dewals BG. 2013. An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle. Proc Natl Acad Sci U S A 110:E1933-E1942. http://dx.doi.org/10.1073/ pnas.1216531110
Cunha CW, Knowles DP, Taus NS, O'Toole D, Nicola AV, Aguilar HC, Li H. 2015. Antibodies to ovine herpesvirus 2 glycoproteins decrease virus infectivity and prevent malignant catarrhal fever in rabbits. Vet Microbiol 175:349-355. http://dx.doi.org/10.1016/ j.vetmic.2014.11.026
Eisenberg RJ, Atanasiu D, Cairns TM, Gallagher JR, Krummenacher C, Cohen GH. 2012. Herpesvirus fusion and entry: a story with many characters. Viruses 4:800-832. http://dx.doi.org/10.3390/v4050800
Lee SK, Compton T, Longnecker R. 1997. Failure to complement infectivity of EBV and HSV-1 glycoprotein B (gB) deletion mutants with gBs from different human herpesvirus subfamilies. Virology 237: 170-181. http://dx.doi.org/10.1006/viro.1997.8765
Miethke A, Keil GM, Weiland F, Mettenleiter TC. 1995. Unidirectional complementation between glycoprotein B homologues of pseudorabies virus and bovine herpesvirus 1 is determined by the carboxy-terminal part of the molecule. J Gen Virol 76:1623-1635. http://dx.doi.org/ 10.1099/0022-1317-76-7-1623
Spiesschaert B, Osterrieder N, Azab W. 2015. Comparative analysis of glycoprotein B (gB) of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in cellular tropism and cell-to-cell transmission. Viruses 7:522-542. http://dx.doi.org/10.3390/v7020522
Li H, Cunha CW, O'Toole D, Nicola AV, Knowles DP, Taus NS. 2013. Development of an in vivo system to measure antibody-blocking of ovine herpesvirus 2 entry. J Virol Methods 188:104-107. http:// dx.doi.org/10.1016/j.jviromet.2012.12.008
Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG. 2005. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res 33:e36
Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. 1998. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A 95:14723-14728. http://dx.doi.org/10.1073/ pnas.95.25.14723
Gillet L, Daix V, Donofrio G, Wagner M, Koszinowski UH, China B, Ackermann M, Markine-Goriaynoff N, Vanderplasschen A. 2005. Development of bovine herpesvirus 4 as an expression vector using bacterial artificial chromosome cloning. J Gen Virol 86:907-917. http:// dx.doi.org/10.1099/vir.0.80718-0
Traul DL, Elias S, Taus NS, Herrmann LM, Oaks JL, Li H. 2005. A real-time PCR assay for measuring alcelaphine herpesvirus-1 DNA J V i r o l Methods 129:186-190. http://dx.doi.org/10.1016/ j.jviromet.2005.05.021
Li H, McGuire TC, Müller-Doblies UU, Crawford TB. 2001. A simpler, more sensitive competitive inhibition ELISA for detection of antibody to malignant catarrhal fever viruses. J Vet Diagn Invest 13: 361-364
Dewals B, Myster F, Palmeira L, Gillet L, Ackermann M, Vanderplasschen A. 2011. Ex vivo bioluminescence detection of alcelaphine herpesvirus 1 infection during malignant catarrhal fever. J Virol 85:6941-6954. http://dx.doi.org/10.1128/JVI.00286-11
Cunha CW, O'Toole D, Taus NS, Knowles DP, Li H. 2013. Are rabbits a suitable model to study sheep-associated malignant catarrhal fever in susceptible hosts? Vet Microbiol 163:358-363. http://dx.doi.org/ 10.1016/j.vetmic.2013.01.002
