Article (Scientific journals)
Prognostic value of echocardiographic and Doppler parameters in horses admitted for colic complicated by systemic inflammatory response syndrome
Borde, L.; Amory, Hélène; Grulke, Sigrid et al.
2014In Journal of Veterinary Emergency and Critical Care, 24 (3), p. 302-310
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Keywords :
Endotoxemia; Equine intensive care; Hemodynamics; Prognosis; Doppler flowmetry; Animals; Colic; Echocardiography; Female; Horse Diseases; Horses; Male; Predictive Value of Tests; Prospective Studies; ROC Curve; Survival Analysis; Systemic Inflammatory Response Syndrome; Ultrasonography, Doppler
Abstract :
[en] Objective: To assess the prognostic value of echocardiographic parameters of left ventricular (LV) function in horses with systemic inflammatory response syndrome (SIRS). Design: Prospective observational study. Setting: Veterinary teaching hospital. Animals: Forty-one horses admitted for colic with clinical evidence of SIRS. Interventions: All horses underwent Doppler echocardiographic examination on admission. LV echocardiographic parameters, including pulsed-wave tissue Doppler imaging parameters, were compared between nonsurvivors (n = 29) and horses that survived to discharge (n = 12). Measurements and Main Results: With comparable heart rate and LV preload estimate, LV stroke volume index, the velocity time integral, deceleration time, ejection time of Doppler aortic flow, and peak early diastolic myocardial velocity were lower in the nonsurviving than in the surviving horses, while pre-ejection period to ejection time ratio (PEP/ET) of Doppler aortic flow and the peak early diastolic filling velocity to peak early diastolic myocardial velocity ratio (E/Em) were higher (P < 0.05). A cut-off value of 0.26 for PEP/ET predicted mortality with 100% sensitivity and 42% specificity (area under the receiver operating characteristic curve: 0.71), whereas a cut-off value of 2.67 for E/Em predicted mortality with 100% sensitivity and 83% specificity (area under the receiver operating characteristic curve: 0.89). Conclusions: Echocardiography may provide prognostic information in colic horses with clinical evidence of SIRS. Especially, PEP/ET and E/Em could be useful markers of systolic and diastolic dysfunction, respectively, to detect horses with a high risk of death requiring more intensive cardiovascular monitoring as it has been reported in human patients with septic shock. © Veterinary Emergency and Critical Care Society 2014.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Borde, L.;  Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, B41, Liège, 4000, Belgium
Amory, Hélène ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Grulke, Sigrid  ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)
Leroux, Aurélia ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
HOUBEN, Rachel ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Detilleux, Johann ;  Université de Liège > Département des productions animales (DPA) > Génétique quantitative
Sandersen, Charlotte  ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires
Language :
English
Title :
Prognostic value of echocardiographic and Doppler parameters in horses admitted for colic complicated by systemic inflammatory response syndrome
Publication date :
2014
Journal title :
Journal of Veterinary Emergency and Critical Care
ISSN :
1479-3261
eISSN :
1476-4431
Publisher :
Blackwell Publishing Ltd
Volume :
24
Issue :
3
Pages :
302-310
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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