[en] Besides its analgesic action, morphine presents antioxidants properties and therefore an interest as inhibitor of MPO. Moreover, it has been proved that morphine can inhibit the ROS production and the PMN degranulation. Therefore, it seems like morphine has a direct action on MPO activities but the exact mechanism of action is still to be elucidated.
The aim of the study is to investigate the potential antioxidant activity of morphine on the peroxidation cycle of MPO, in comparison to another peroxidase, Horseradish Peroxidase (HRP).
Research center :
centre de l'oxygène
Disciplines :
Physics
Author, co-author :
Hoebeke, Maryse ; Université de Liège > Département de physique > Spectroscopie biomédicale
Nyssen, Pauline ; Université de Liège - ULiège > Master sc. phys., fin. appr. (ex 2e master)
Franck, Thierry ; Université de Liège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
MINGUET, Grégory ; Centre Hospitalier Universitaire de Liège - CHU > Service d'anesthésie - réanimation
Serteyn, Didier ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Mouithys-Mickalad, Ange ; Université de Liège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Language :
English
Title :
Study of the antioxidant action of morphine on the peroxidase cycle of MPO and HRP
Alternative titles :
[en] Study of the antioxidant action of morphine on the peroxidase cycle of MPO and HRP
