Article (Scientific journals)
Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency
Verhaeghe, J.; Bougoussa, M.; Van Herck, E. et al.
2000In Clinical Endocrinology, 53 (5), p. 645-647
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Keywords :
pit-1 deficiency; hPGH; IGF-I
Abstract :
[en] The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and IGF-I in a woman with pit-1 deficiency before, during and after pregnancy, resulting in the birth of a healthy child (not pit-1 deficient). Both PGH and IGF-I concentrations were below the assay detection limit before and after pregnancy. During pregnancy, PGH and IGF-I levels increased steadily; the concentrations of PGH and IGF-I in late pregnancy were comparable with levels previously measured in normal pregnancies. PGH and IGF-I concentrations were strongly correlated throughout pregnancy (r = 0.90; P = 0.002). PGH was undetectable in cord serum, whilst the IGF-I concentration was within the normal range. The findings of this case study corroborate the notion that PGH is the prime regulator of maternal serum IGF-I during pregnancy.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Verhaeghe, J.
Bougoussa, M.
Van Herck, E.
de Zegher, F.
Hennen, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
Igout, Ahmed ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency
Publication date :
2000
Journal title :
Clinical Endocrinology
ISSN :
0300-0664
eISSN :
1365-2265
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
53
Issue :
5
Pages :
645-647
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 December 2008

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