Article (Scientific journals)
Determinants of gastro-protective drugs co-prescription during treatment with nonselective NSAIDs: a prospective survey of 2197 patients recruited in primary care
Rabenda, Véronique; Burlet, N.; Belaiche, Jacques et al.
2006In Osteoarthritis and Cartilage, 14 (7), p. 625-630
Peer Reviewed verified by ORBi
 

Files


Full Text
det gastro pro.pdf
Publisher postprint (155.72 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
nonsteroidal anti-inflammatory drugs; adverse events; gastro-protective drugs; osteoarthritis; treatment; co-prescription
Abstract :
[en] Objective: Our goal was to identify the magnitude of gastro-protective drugs (GPDs) co-prescription and the profile of patients who received GPD co-prescription, during nonsteroidal anti-inflammatory drugs (NSAIDs) treatment in a "real life setting" of primary care practice. Methods: A pragmatic prospective 6-month survey of 2197 new takers of nonselective NSAIDs, selected and followed by general practitioners (GPs) on the bias of their usual standards of care. Results: Forty-seven percent of our survey population used at least one GPD during the 6-month follow-up. No difference was identified between piroxicam, diclofenac, ibuprofen, meloxicam and nimesulid for the GPD co-prescription. Besides the presence of gastro-intestinal (GI) symptoms, previous use of GPD, previous occurrence of GI disorders and increase in age are the most prominent predictive factors of GPD use during NSAID treatment. When adjusted for other risk factors, co-prescription of GPD was significantly increased in patients aged 55 years and above (odds ratio (OR): 1.29, 95% confidence interval (Cl): 1.01-1.64) with no further increase in the co-prescription in older subjects. Conclusion: Patients above 55 years with previous history of GI symptoms or GPD use are more likely to benefit from cytoprotective medications. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Disciplines :
Rheumatology
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Rabenda, Véronique ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Burlet, N.
Belaiche, Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Raeman, F.
Richy, F.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Language :
English
Title :
Determinants of gastro-protective drugs co-prescription during treatment with nonselective NSAIDs: a prospective survey of 2197 patients recruited in primary care
Publication date :
July 2006
Journal title :
Osteoarthritis and Cartilage
ISSN :
1063-4584
eISSN :
1522-9653
Publisher :
W B Saunders Co Ltd, London, United Kingdom
Volume :
14
Issue :
7
Pages :
625-630
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 August 2009

Statistics


Number of views
82 (7 by ULiège)
Number of downloads
6 (6 by ULiège)

Scopus citations®
 
4
Scopus citations®
without self-citations
3
OpenCitations
 
6

Bibliography


Similar publications



Contact ORBi