ORBi: Le Goff Caroline - Pseudomembranous colitis with Clostridium difficile during treatment by moxifloxacine (quinolone)

Reference : Pseudomembranous colitis with Clostridium difficile during treatment by moxifloxacine (q...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Human health sciences : Laboratory medicine & medical technology Human health sciences : Gastroenterology & hepatology
	To cite this reference:	http://hdl.handle.net/2268/1998

Title :	Pseudomembranous colitis with Clostridium difficile during treatment by moxifloxacine (quinolone)
Language :	English
Author, co-author :	Le Goff, Caroline [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
	Wiesen, Patricia [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
	Collette, Julien [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
	Preiser, Jean-Charles [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
	Kaux, Jean-François [Université de Liège - ULg > Département des sciences de la motricité > Médecine physique et réadaptation fonctionnelle >]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Publication date :	27-Oct-2005
Peer reviewed :	No
On invitation :	No
Audience :	National
Event name :	Symposium Annuel de la Société Belge de Biologie Clinique (S.B.B.C.)
Event date :	27 octobre 2008
Event place (city) :	Liège
Event country :	Begium
Keywords :	[en] Pseudomembranous colitis ; Clostridium difficile ; moxifloxacine
Abstract :	[en] C. difficile is the most frequently pathogenic agent isolated in colitis associated with antibiotics and pseudomembranous colitis (PMC). C. difficile takes advantage of the disturbance of the intestinal flora to settle. We report a case of PMC appeared during treatment with moxifloxacine in a pulmonary infection in an emphysematous patient. The diarrhea is generally benign, but can be severe, with toxic megacolon or even the extreme case of colic perforation. The diagnosis is based on the research of toxins of C. difficile (A and/or B) in the intestinal stools or liquids (collected at the time of the endoscopic examination) to which is associated the anaerobic culture on selective agar. The reference method is the measurement of the cytotoxic effect of the B-toxin on a cell culture. Metronidazole or vancomycine constitutes the treatment. The prevention of relapses is very important, hygiene measures and probiotic agents must be associated to the antibiotic treatment.
Target :	Professionals ; Students
Permalink :	http://hdl.handle.net/2268/1998

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