Article (Scientific journals)
Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.
Frederich, Michel; Pirotte, Bernard; Fillet, Marianne et al.
2016In Journal of Medicinal Chemistry, 59 (19), p. 8649–8666
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Abstract :
[en] "Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at different levels, starting from the most fundamental, i.e., the genome, and finishing with the most functional, i.e., the metabolome. Similar to how genomics is applied to the exploration of DNA, metabolomics is the qualitative and quantitative study of metabolites. This emerging field is clearly linked to genomics, transcriptomics, and proteomics. In addition, metabolomics provides a unique and direct vision of the functional outcome of an organism's activities that are required for it to survive, grow, and respond to internal and external stimuli or stress, e.g., pathologies and drugs. The links between metabolic changes, patient phenotype, physiological and/or pathological status, and treatment are now well established and have opened a new area for the application of metabolomics in the drug discovery process and in personalized medicine.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel  ;  Université de Liège > Département de pharmacie > Pharmacognosie
Pirotte, Bernard ;  Université de Liège > Département de pharmacie > Chimie pharmaceutique
Fillet, Marianne ;  Université de Liège > Département de pharmacie > Analyse des médicaments
De Tullio, Pascal ;  Université de Liège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.
Publication date :
2016
Journal title :
Journal of Medicinal Chemistry
ISSN :
0022-2623
eISSN :
1520-4804
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
59
Issue :
19
Pages :
8649–8666
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 July 2016

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