The Role of Post-Translational Modifications in Hearing and Deafness

[en] Post-translational modifications (PTMs) are key molecular events that modify proteins after their synthesis and modulate their ultimate functional properties by affecting their stability, localisation, interaction potential or activity. These chemical changes expand the size of the proteome adding diversity to the molecular pathways governing the biological outcome of cells. PTMs are thus crucial in regulating a variety of cellular processes such as apoptosis, proliferation and differentiation and have been shown to be instrumental during embryonic development. In addition, alterations in protein PTMs have been implicated in the pathogenesis of many human diseases, including deafness. In this review, we summarize the recent progress made in understanding the roles of PTMs during cochlear development, with particular emphasis on the enzymes driving protein phosphorylation, acetylation, methylation, glycosylation, ubiquitination and SUMOylation. We also discuss how these enzymes may contribute to hearing impairment and deafness.

Disciplines :

Biochemistry, biophysics & molecular biology
Otolaryngology

Author, co-author :

Mateo Sanchez, Susana ; Université de Liège > GIGA - Neurosciences

Freeman, Stephen ; Université de Liège > GIGA - Neurosciences

Delacroix, Laurence ; Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Malgrange, Brigitte ; Université de Liège > GIGA - Neurosciences

Language :

English

Title :

The Role of Post-Translational Modifications in Hearing and Deafness

Publication date :

2016

Journal title :

Cellular and Molecular Life Sciences

ISSN :

1420-682X

eISSN :

1420-9071

Publisher :

Birkhäuser, Basel, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 June 2016

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127 (20 by ULiège)

Number of downloads

4 (4 by ULiège)

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