[en] Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitt’s lymphoma. This is a rare location of sporadic Burkitt’s lymphoma with neurologic syndrome as first symptoms.
Disciplines :
Oncology Pediatrics Hematology
Author, co-author :
Hoyoux, Claire ; Université de Liège > Département des sciences cliniques > Département des sciences cliniques
FORGET, Patricia ; Centre Hospitalier Universitaire de Liège - CHU > Service de pédiatrie (CHR)
Piette, Caroline ; Université de Liège > Département des sciences cliniques > Pédiatrie
DRESSE, Marie-Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Service de pédiatrie (CHR)
Gunes D., Uysal K. M., Cetinkaya H., Tekin H. G., Yuceer N., Sarialioglu F., Olgun N., Paravertebral malignant tumors of childhood: analysis of 28 pediatric patients. Child's Nervous System 2009 25 1 63 69 2-s2.0-57449117901 10.1007/s00381-008-0717-2
Ortega J. A., Wharam M., Gehan E. A., Ragab A. H., Crist W., Webber B., Wiener E. S., Haeberlen V., Maurer H. M., Clinical features and results of therapy for children with paraspinal soft tissue sarcoma: a report of the intergroup rhabdomyosarcoma study. Journal of Clinical Oncology 1991 9 5 796 801 2-s2.0-0025892056
Cairo M. S., Sposto R., Perkins S. L., Meadows A. T., Hoover-Regan M. L., Anderson J. R., Siegel S. E., Lones M. A., Tedeschi-Blok N., Kadin M. E., Kjeldsberg C. R., Wilson J. F., Sanger W., Morris E., Krailo M. D., Finlay J. L., Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the children's cancer group experience. British Journal of Haematology 2003 120 4 660 670 2-s2.0-0345701969 10.1046/j.1365-2141.2003.04134.x (Pubitemid 36255868)
Daley M. F., Partington M. D., Kadan-Lottick N., Odom L. F., Primary epidural burkitt lymphoma in a child: case presentation and literature review. Pediatric Hematology and Oncology 2003 20 4 333 338 2-s2.0-0038778568 (Pubitemid 36648199)
Adegboye O. A., Non-Hodgkin's lymphoma "masquerading" as pott's disease in a 13-year old boy. Indian Journal of Medical and Paediatric Oncology 2011 32 2 101 104
Massarelli G., Onida G. A., Piras M. A., Marras V., Mura A., Tanda F., Neuron-specific enolase expression in hodgkin's disease and large cell lymphomas. Anticancer Research 1999 19 5B 3933 3938 2-s2.0-0032763983
Wang L., Liu P., Geng Q., Chen X., Lv Y., Prognostic significance of neuron-specific enolase in patients with diffuse large B-cell lymphoma treated with rituximab-based immunochemotherapy. Leukemia and Lymphoma 2011 52 9 1697 1703
Pelinka L. E., Serum markers of severe traumatic brain injury: are they useful? Indian Journal of Critical Care Medicine 2005 8 3 190 193 2-s2.0-22144490899
Salzburg J., Burkhardt B., Zimmermann M., Wachowski O., Woessmann W., Oschlies I., Klapper W., Wacker H. H., Ludwig W. D., Niggli F., Mann G., Gadner H., Riehm H., Schrappe M., Reiter A., Prevalence, clinical pattern, and outcome of CNS involvement in childhood and adolescent non-Hodgkin's lymphoma differ by non-hodgkin's lymphoma subtype: a berlin-frankfurt-munster group report. Journal of Clinical Oncology 2007 25 25 3915 3922 2-s2.0-34548536531 10.1200/JCO.2007.11.0700 (Pubitemid 47477269)
Mora J., Wollner N., Primary epidural non-hodgkin lymphoma: spinal cord compression syndrome as the initial form of presentation in childhood non-hodgkin lymphoma. Medical and Pediatric Oncology 1999 32 2 102 105 (Pubitemid 29053006)
Chahal S., Lagera J. E. R., Ryder J., Kleinschmidt-DeMasters B. K., Hematological neoplasms with first presentation as spinal cord compression syndromes: a 10-year retrospective series and review of the literature. Clinical Neuropathology 2003 22 6 282 290 2-s2.0-0346121402 (Pubitemid 37541367)
Dechambenoit G., Piquemal M., Giordano C., Cournil C., Ba Zeze V., Santini J. J., Spinal cord compression resulting from burkitt's lymphoma in children. Child's Nervous System 1996 12 4 210 214 2-s2.0-0030011564 10.1007/BF00301252 (Pubitemid 26156770)
Ses E., N'Dri Oka D., Varlet G., Koffi K., Boni N. R., Ba Zeze V., Spinal cord compression secondary to burkitt's lymphoma. An analysis of 7 cases. Neurochirurgie 2001 47 6 552 556 2-s2.0-0035666846 (Pubitemid 34019427)
Turgut M., Ozcan O. E., Erbengi A., Burkitt's lymphoma: an unusual cause of childhood paraplegia. Child's Nervous System 1991 7 3 169 171 2-s2.0-0025905626
Gupta V., Srivastava A., Bhatia B., Hodgkin disease with spinal cord compression. Journal of Pediatric Hematology Oncology 2009 31 10 771 773 2-s2.0-70349792601 10.1097/MPH.0b013e31819c1ff0
Biko D. M., Anupindi S. A., Hernandez A., Kersun L., Bellah R., Childhood burkitt lymphoma: abdominal and pelvic imaging findings. American Journal of Roentgenology 2009 192 5 1304 1315 2-s2.0-65649106217 10.2214/AJR.08.1476