Reference : Structure of the tilapia (Oreochromis mossambicus) prolactin I gene
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Structure of the tilapia (Oreochromis mossambicus) prolactin I gene
Swennen, D. [> > > >]
Poncelet, A. C. [ > > ]
Sekkali, B. [> > > >]
Rentier-Delrue, Françoise mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire - GIGA-R : Coordination scientifique >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Belayew, A. [> > > >]
DNA & Cell Biology
Mary Ann Liebert, Inc.
Yes (verified by ORBi)
[en] Amino Acid Sequence ; Animals ; Base Sequence ; Blotting, Southern ; Cloning, Molecular ; Dna ; Humans ; Molecular Sequence Data ; Prolactin/*genetics ; Restriction Mapping ; Sequence Homology, Amino Acid ; Tilapia ; Transcription, Genetic
[en] The tilapia (Oreochromis mossambicus) prolactin-I (PRL-I) gene has been cloned and sequenced. Its transcript (3,677 bases long) begins with a guanine and is organized in five exons and four introns like the other known prolactin genes. Analysis of the 1,555-bp 5'-flanking region suggests that pituitary-specific expression of the gene could be regulated through a trans-factor related to the mammalian pituitary-specific factor Pit-1. Two potential binding sites for such a factor were found in the first intron, suggesting a possible regulatory role for this region. Moreover, two potential Z-DNA regions are located at positions -837 to -812 and -246 to -179 from the transcription start site. These two regions could play an important role in the regulation of PRL gene expression.

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