Régulation transcriptionnelle du gène de la prolactine humaine

Muller, Marc; Berwaer, Monique; Caccavelli, Laure; Manfroid, Isabelle; Nalda, Asuncion; Pendeville-Samain, Hélène; Pernasetti, F.; Van de Weerdt, Cécile; Peers, Bernard; Martial, Joseph

doi:10.4267/10608/1096

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Régulation transcriptionnelle du gène de la prolactine humaine

Muller, Marc; Berwaer, Monique; Caccavelli, Laure et al.

1998 • In MS. Medecine Sciences, 14 (580-587)

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10.4267/10608/1096

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Keywords :

Prolactin; Gene; Regulation

Abstract :

[fr] Le gène humain de la prolactine (hPRL) est exprimé essentiellement par l'antéhypophyse. L'analyse des éléments régulateurs de la transcription sur plus de 5 000 bases en amont du site de début de transcription a montré l'importance du contrôle par le facteur de transcription Pit-1, spécifique de l'hypophyse, à côté de facteurs ubiquistes. Des hormones modulent l'expression du gène hPRL, transmettant leur signal par les voies intracellulaires de l'AMP cyclique et du calcium, relayées au niveau du promoteur proximal (-250/+1) essentiellement par les facteurs de transcription Pit-1 et AP-1. Les récepteurs nucléaires contrôlent aussi en partie la transcription de hPRL: le récepteur des oestrogènes l'active en se liant aux éléments de réponse distaux ; les récepteurs nucléaires des hormones thyroïdiennes et des glucocorticoïdes la répriment en interférant respectivement avec la fonction activatrice de AP-1 et de Pit-1.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Muller, Marc ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Berwaer, Monique

Caccavelli, Laure

Manfroid, Isabelle ; Université de Liège - ULiège > GIGA-Research

Nalda, Asuncion

Pendeville-Samain, Hélène ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Pernasetti, F.

Van de Weerdt, Cécile ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Peers, Bernard ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire

Language :

French

Title :

Régulation transcriptionnelle du gène de la prolactine humaine

Alternative titles :

[en] Transcriptional regulation of the human prolactin gene

Publication date :

1998

Journal title :

MS. Medecine Sciences

ISSN :

0767-0974

eISSN :

1958-5381

Publisher :

EDK, Paris, France

Volume :

Issue :

580-587

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 August 2009

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