No full text
Poster (Scientific congresses and symposiums)
Estetrol : a new natural estrogen providing a safe therapeutic window for the treatment of menopause
Gérard, Céline; Gallez, Anne; Silva, Elisabete et al.
2015Congrès de la Société Belge de la Ménopause (BMS)
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Estetrol; Estrogen Receptor; Hormone Replacement Therapy
Abstract :
[en] The increased risk of breast cancer and thromboembolism in women who take hormone replacement therapy (HRT) is a major public health problem. The discovery of new drugs with better safety profile would provide useful advances for patient care. Estetrol (E4) is a liver friendly promising candidate for HRT. In preclinical and/or clinical studies, E4 has been effective against the main symptoms of menopause from a starting dose of 0.3 mg/kg/day. The aim of this study was to define the impact of E4 on mammary gland and breast cancer development. Our preclinical data show that E4 is less efficient than estradiol (E2) to induce mammary gland growth. Treatment with several concentrations of E4 has shown that E4 did not increase tumor development, when it is used at 0.3 mg/kg/day. However, at 3 mg/kg/day, E4 increased tumor growth similarly to E2 (0.08 mg/kg/day). E4 presents also some anti-estrogenic effects on mammary gland and antitumor activity on breast cancer by decreasing the strong proliferative effect of E2. While ERα is the predominant receptor mediating its effects, the dual weak-estrogenic/anti-estrogenic feature of E4 results from differential signaling pathways activation. Both nuclear and rapid extra-nuclear signaling pathways are necessary for a complete estrogenic effect of E4. However, the antitumor action of E4 is not due to a capacity to antagonize E2-induced nuclear activity. In conclusion, our results support that E4, if it is used in strictly controlled clinical applications, could have no or only limited impact on breast and breast cancer.
Disciplines :
Oncology
Author, co-author :
Gérard, Céline ;  Université de Liège > R&D Direction : Chercheurs ULiège en mobilité
Gallez, Anne ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Silva, Elisabete;  Institute of Environment, Health and Societies, Brunel University London, UB83PH Uxbridge, United Kingdom
Gompel, Anne;  Gynaecological Endocrinology Unit, Paris Descartes University, Hôpitaux Universitaires, Paris, France
Lenfant, Françoise;  INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, University of Toulouse, UPS, Toulouse, France
Arnal, Jean-François;  INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, University of Toulouse, UPS, Toulouse, France
Foidart, Jean-Michel ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Pequeux, Christel  ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Estetrol : a new natural estrogen providing a safe therapeutic window for the treatment of menopause
Publication date :
14 November 2015
Event name :
Congrès de la Société Belge de la Ménopause (BMS)
Event organizer :
Société Belge de la Ménopause (BMS)
Event place :
Bruxelles, Belgium
Event date :
From 14th November 2015 to 14th November 2015
Available on ORBi :
since 07 June 2016

Statistics


Number of views
119 (7 by ULiège)
Number of downloads
1 (1 by ULiège)

Bibliography


Similar publications



Contact ORBi