[en] The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.
Disciplines :
Pharmacy, pharmacology & toxicology Chemistry
Author, co-author :
Manos-Turvey, Alexandra ; University of Pittsburgh -PITT > Department of Biological Sciences and Department of Chemistry
Watson, Emma E.
Sykes, Melissa L.
Jones, Amy J.
Baell, Jonathan B.
Kaiser, Marcel
Avery, Vicky M.
Payne, Richard J.
Language :
English
Title :
Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents
Publication date :
2015
Journal title :
MedChemComm
ISSN :
2040-2503
eISSN :
2040-2511
Publisher :
Royal Society of Chemistry, London, United Kingdom
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