Article (Scientific journals)
Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.
Gladwyn-Ng, Ivan; Huang, Lieven; Ngo, Linh et al.
2016In Neural Development, 11, p. 7
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Keywords :
Bacurd; Dendritic branching; Dendritic spines; Neuronal migration
Abstract :
[en] BACKGROUND: The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiation and dendritic spine connectivity. The RhoA GTPases Rnd2 and Rnd3 are important for neurogenesis and cell migration within the embryonic cortex (Nat Commun 4:1635, 2013), and we recently identified the BTB/POZ domain-containing Adaptor for Cul3-mediated RhoA Degradation family member Bacurd2 (also known as Tnfaip1) as an interacting partner to Rnd2 for the migration of embryonic mouse cortical neurons (Neural Dev 10:9, 2015). FINDINGS: We have extended this work and report that Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd2 and Rnd3 in vitro. Given that these genes are expressed during cortical development, we performed a series of in utero electroporation studies in mice and found that disruptions to Bacurd1/Kctd13 or Bacurd2/Tnfaip1 expression impair the long-term positioning of E14.5-born cortical neurons within the postnatal (P17) mouse cerebral cortex. We also find that forced expression of Bacurd1/Kctd13 and Bacurd2/Tnfaip1 alters the branching and dendritic spine properties of layer II/III projection neurons. CONCLUSIONS: We identify Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to Rnd proteins which influence the development of cortical neurons. Their neurodevelopmental functions are likely to be relevant to human brain development and disease.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Gladwyn-Ng, Ivan ;  Université de Liège > Giga - Neurosciences
Huang, Lieven
Ngo, Linh
Li, Shan Shan
Qu, Zhengdong
Vanyai, Hannah Kate
Cullen, Hayley Daniella
Davis, John Michael
Heng, Julian Ik-Tsen
Language :
English
Title :
Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.
Publication date :
2016
Journal title :
Neural Development
eISSN :
1749-8104
Publisher :
BioMed Central, United Kingdom
Volume :
11
Pages :
7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 June 2016

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