Article (Scientific journals)
Modulation of acetylcholine, capsaicin and substance P effects by histamine H3 receptors in isolated perfused rabbit lungs.
Delaunois, Annie; Gustin, Pascal; Garbarg, M. et al.
1995In European Journal of Pharmacology, 277 (2-3), p. 243-50
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Keywords :
Acetylcholine/metabolism/toxicity; Animals; Capillary Permeability/drug effects; Capsaicin/metabolism/toxicity; Dose-Response Relationship, Drug; Drug Interactions; Endothelium/drug effects/metabolism; Female; Histamine Agonists/pharmacology; Histamine Antagonists/pharmacology; Imidazoles/pharmacology; Lung/drug effects; Male; Nerve Fibers/drug effects/metabolism; Piperidines/pharmacology; Pulmonary Edema/chemically induced/metabolism; Rabbits; Receptors, Histamine H3/drug effects/metabolism; Serotonin/metabolism/toxicity; Substance P/metabolism/toxicity; Thiourea/analogs & derivatives/pharmacology
Abstract :
[en] The modulatory role of histamine H3 receptors in pulmonary oedema induced by acetylcholine, capsaicin and by exogenous substance P was investigated in isolated, ventilated rabbit lungs. Endothelial permeability was evaluated by measuring the capillary filtration coefficient (Kf,c). Acetylcholine (10(-8) to 10(-4) M), substance P (10(-10) to 10(-6) M), capsaicin (10(-4) M) and 5-hydroxytryptamine (5-HT) (10(-4) M) induced an increase in the Kf,c. Carboperamide, a novel histamine H3 receptor antagonist, induced a significant leftward shift of the concentration-response curve to acetylcholine and also enhanced the effect of capsaicin on the Kf,c, while it had no significant effect on the response to substance P and 5-HT. Imetit, a new histamine H3 receptor agonist, strongly inhibited the effects of acetylcholine and capsaicin. Imetit also strongly protected the lung against substance P effects but did not prevent the 5-HT-induced increase in the Kf,c. Carboperamide completely blocked the inhibitory effect of Imetit on the acetylcholine response. (R)-alpha-Methylhistamine, an other histamine H3 receptor agonist, had the same protective effect against acetylcholine response as Imetit. We conclude that histamine H3 receptors could protect the lung against acetylcholine- and capsaicin-induced oedema via a prejunctional modulatory effect on the C-fibres. However, since the response to exogenous substance P was also inhibited by histamine H3 receptor stimulation, the presence of such receptors at a postsynaptic level, probably on mast cells, was also suggested.
Disciplines :
Veterinary medicine & animal health
Pharmacy, pharmacology & toxicology
Author, co-author :
Delaunois, Annie ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Gustin, Pascal ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Garbarg, M.
Ansay, Michel ;  Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire)
Language :
English
Title :
Modulation of acetylcholine, capsaicin and substance P effects by histamine H3 receptors in isolated perfused rabbit lungs.
Publication date :
1995
Journal title :
European Journal of Pharmacology
ISSN :
0014-2999
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
277
Issue :
2-3
Pages :
243-50
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 August 2009

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