Article (Scientific journals)
Efficacy of the RemoweLL cardiotomy reservoir for fat and leucocyte removal from shed mediastinal blood: a randomized controlled trial.
LAGNY, Marc-Gilbert; GOTHOT, André; HANS, Grégory et al.
2016In Perfusion
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Keywords :
leucocyte removal; lipids; filtration; cardiotomy reservoir; cardiopulmonary bypass
Abstract :
[en] Efficacy of the RemoweLL cardiotomy reservoir for Fat and Leucocyte removal from shed mediastinal blood: a randomized controlled trial. ABSTRACT (176 words) Introduction Re-transfusion of lipid particles and activated leucocytes with shed mediastinal blood (SMB) can aggravate cardiopulmonary bypass-associated inflammation and increase the embolic load. This study evaluated the fat and leucocyte removal capacity of the RemoweLL cardiotomy reservoir. Methods Forty-five patients undergoing elective on-pump cardiac surgery were randomly allocated to filtration of SMB using the RemoweLL or the Admiral cardiotomy reservoir. The primary outcome was the drop in leucocytes and lipid particles obtained with the two filters. The effect of the filters on other blood cells and inflammatory mediators such as myeloperoxidase (MPO) was also assessed. Results The RemoweLL cardiotomy filter removed 16.5 % of the leucocytes (P < 0.001) while no significant removal of leucocytes was observed with the Admiral (P = 0.48). The percentage reductions in lipid particles were similar in the two groups (26% vs 23 %, P = 0.2). Both filters similarly affected the level of MPO (P = 0.71). Discussion The RemoweLL filter more effectively removed leucocytes from SMB than the Admiral. It offered no advantage in term of lipid particle clearance.
Disciplines :
Surgery
Author, co-author :
LAGNY, Marc-Gilbert ;  Centre Hospitalier Universitaire de Liège - CHU > Bloc opératoire chirurgie cardio-vasculaire (+1BC)
GOTHOT, André ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie biologique et immuno-hématologie
HANS, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'anesthésie - réanimation
KOCH, Jean-Noël ;  Centre Hospitalier Universitaire de Liège - CHU > Bloc opératoire chirurgie cardio-vasculaire (+1BC)
BLAFFART, Francine ;  Centre Hospitalier Universitaire de Liège - CHU > Bloc opératoire chirurgie cardio-vasculaire (+1BC)
HELLA, Dominique ;  Centre Hospitalier Universitaire de Liège - CHU > Bloc opératoire chirurgie cardio-vasculaire (+1BC)
Donneau, Anne-Françoise ;  Université de Liège > Département des sciences de la santé publique > Biostatistique
ROEDIGER, Laurence ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'anesthésie - réanimation
LECUT, Christelle ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'hématologie biologique et immuno-hématologie
PINCEMAIL, Joël ;  Centre Hospitalier Universitaire de Liège - CHU > Service de chirurgie cardio-vasculaire et thoracique
CHERAMY-BIEN, Jean-Paul  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de chirurgie cardio-vasculaire et thoracique
DEFRAIGNE, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Service de chirurgie cardio-vasculaire et thoracique
Language :
English
Title :
Efficacy of the RemoweLL cardiotomy reservoir for fat and leucocyte removal from shed mediastinal blood: a randomized controlled trial.
Publication date :
16 May 2016
Journal title :
Perfusion
ISSN :
0267-6591
eISSN :
1477-111X
Publisher :
SAGE Publications, London, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 May 2016

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