[en] The cardiovascular and respiratory parameters of eight laboratory beagles were measured before and after the simultaneous injection of medetomidine (40 micrograms/kg bw) and ketamine (5 mg/bg bw). This combination produced a significant alteration in cardiovascular function. The heart rate, the stroke volume and cardiac output decreased while the systemic vascular resistance increased. These effects were attributed principally to the alpha 2 agonist compound combined with the moderate stimulatory effect of ketamine. The respiratory parameters were little affected by this protocol.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Coppens, P.
Jones, R.
Verstegen, J.
Philippart, C.
Lamy, Maurice ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Language :
English
Title :
Circulatory and Respiratory Effects of the Combination Medetomidine-Ketamine in Beagles
Publication date :
June 1993
Journal title :
Journal of Veterinary Pharmacology and Therapeutics
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