Reference : Mechanisms of HTLV-1 persistence and transformation.

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/19687

Title :	Mechanisms of HTLV-1 persistence and transformation.
Language :	English
Author, co-author :	Boxus, Mathieu [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
	Willems, Luc [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Publication date :	2009
Journal title :	British Journal of Cancer
Publisher :	Nature Publishing Group
Volume :	101
Issue/season :	9
Pages :	1497-501
Audience :	International
ISSN :	0007-0920
e-ISSN :	1532-1827
City :	London
Country :	United Kingdom
Keywords :	[en] Basic-Leucine Zipper Transcription Factors/physiology ; Cell Transformation, Viral ; DNA Damage ; Gene Products, rex/physiology ; Gene Products, tax/physiology ; Genomic Instability ; Human T-lymphotropic virus 1/genetics/physiology ; Humans ; Leukemia-Lymphoma, Adult T-Cell/pathology/virology ; T-Lymphocytes/pathology ; Viral Proteins/physiology ; Virus Replication
Abstract :	[en] Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.
Permalink :	http://hdl.handle.net/2268/19687
DOI :	10.1038/sj.bjc.6605345

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