Article (Scientific journals)
Impacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment
Leroi, Natacha; LALLEMAND, François; COUCKE, Philippe et al.
2016In Frontiers in Pharmacology, 7, p. 1-9
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Keywords :
radiotherapy; tumor microenvironment; angiogenesis; hypoxia; inflammation; cancer-associated fibroblasts; treatment combination
Abstract :
[en] During the last decade, the initial cancer cell-centered view of tumors has greatly evolved to an integrated vision of tumor biology taking into account the key contribution of the TME. Obviously, the different compartments of TME are closely related and contribute not only to tumor progression, but also to its response to treatments. Importantly, the TME evolves over time during the different steps of cancer development and is also affected by different therapeutic modalities. Although, improvements have been achieved regarding RT delivery to the primary tumor, ionizing radiation also target nontumor cells that influence tumor growth and metastatic dissemination. Different approaches have been proposed to overcome the radioresistance of cancer cells. The TME-mediated radioresistance is now the object of researches, which has been elegantly reviewed recently by Barker et al. (2015) and severalarticles pointed out the importance of treatments that modify the TME and likely radiosensitize tumor (Ansiaux et al., 2005; Crokart et al., 2005b; Frérart et al., 2008). However, the impact of anti-cancer treatments on the TME and consequently on the tumor phenotype, response to treatment and metastases, is often neglected. Here we pointed out the impact of RT on the TME. Recent findings emphasize the interest to optimize RT (i.e., dose per fraction) and timing of surgery (Leroi et al., 2015; Surace et al., 2015) in order to prevent metastatic spreading. The future challenge in RT will be to define the most appropriate combinations between RT, and other therapeutic modalities with the optimal sequence and timing of treatments. In this context, investigation of the TME-related acquired resistance will be essential and will provide important innovative data.
Disciplines :
Oncology
Author, co-author :
Leroi, Natacha ;  Université de Liège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire
LALLEMAND, François  ;  Centre Hospitalier Universitaire de Liège - CHU > Radiothérapie
COUCKE, Philippe  ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiothérapie
Noël, Agnès ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
MARTINIVE, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiothérapie
Language :
English
Title :
Impacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment
Alternative titles :
[fr] Impacts des rayonnements ionisants sur les différents compartiments du micro environnement de la tumeur
Publication date :
30 March 2016
Journal title :
Frontiers in Pharmacology
ISSN :
1663-9812
Publisher :
Frontiers Media
Volume :
7
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRSM - Fonds de la Recherche Scientifique Médicale [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
Fonds Léon Fredericq [BE]
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