Article (Scientific journals)
L'etude UPLIFT (Understanding Potential Long-term Impacts on Function with Tiotropium).
Corhay, Jean-Louis; Louis, Renaud
2009In Revue Médicale de Liège, 64 (1), p. 52-7
Peer reviewed
 

Files


Full Text
L'etude clinique du mois_L'etude UPLIFT (Understanding Potential Long-term Impacts on Function with Tiotropium)_Corhay_09_RevMedLg.pdf
Publisher postprint (757.53 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
COPD; Exacerbation; Long acting anticholinergics; Lung function; Quality of life
Abstract :
[en] The UPLIFT study (Understanding Potential Long-term Impacts on Function with Tiotropium) was a double-blind, randomised, international, multicentric, placebo-controlled clinical trial, investigating with tiotropium (Spiriva) the change in the annual rate of decline in FEV1 in chronic obstructive pulmonary disease (COPD). Secondary end points included COPD exacerbation rate with or without hospitalisation, lung function, quality of life and mortality. 5.993 patients were randomized. In this article, we briefly describe the most important results of the study. While tiotropium did not alter the annual rate of decline in FEV1 (pre and postbronchodilatation), it improved lung function and quality of life, and reduced exacerbations and hospitalisations by comparison with control for up to 4 years. Tiotropium also reduced respiratory and cardiac morbidity.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Corhay, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
French
Title :
L'etude UPLIFT (Understanding Potential Long-term Impacts on Function with Tiotropium).
Alternative titles :
[en] The UPLIFT study (Understanding Potential Long-term Impacts on Function with Tiotropium)
Publication date :
2009
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
64
Issue :
1
Pages :
52-7
Peer reviewed :
Peer reviewed
Available on ORBi :
since 24 August 2009

Statistics


Number of views
479 (1 by ULiège)
Number of downloads
518 (1 by ULiège)

Scopus citations®
 
4
Scopus citations®
without self-citations
4

Bibliography


Similar publications



Contact ORBi