Fun stories about Brucella: the "furtive nasty bug".

Animals; Brucella/cytology/pathogenicity/physiology; Brucellosis/microbiology/veterinary; Cell Communication; Cell Cycle/genetics; Flagella/genetics; Humans; Luminescent Measurements; Vibrio/pathogenicity/physiology; Zoonoses/epidemiology

Abstract :

[en] Although Brucella is responsible for one of the major worldwide zoonosis, our understanding of its pathogenesis remains in its infancy. In this paper, we summarize some of the research in progress in our laboratory that we think could contribute to a better understanding of the Brucella molecular virulence mechanisms and their regulation.

Disciplines :

Microbiology

Author, co-author :

Letesson, Jean-Jacques

Lestrate, Pascal

Delrue, Rose-May

DANESE, Isabelle

Bellefontaine, Flore

Fretin, David

Taminiau, Bernard ; Université de Liège - ULiège > Département des Sciences des denrées alimentaires > Secteur Microbiologie

Tibor, Anne

Dricot, Amélie

Deschamps, Chantal

More authors (6 more)

Language :

English

Title :

Fun stories about Brucella: the "furtive nasty bug".

Publication date :

December 2002

Journal title :

Veterinary Microbiology

ISSN :

0378-1135

eISSN :

1873-2542

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

Issue :

1-4

Pages :

317-28

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 28 April 2016

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Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.C., Davis R.W., Federspiel N.A., Long S.R. Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid. Proc. Natl. Acad. Sci. U.S.A. 98:2001a;9883-9888.
Barnett M.J., Hung D.Y., Reisenauer A., Shapiro L., Long S.R. A homolog of the CtrA cell cycle regulator is present and essential in Sinorhizobium meliloti. J. Bacteriol. 183:2001b;3204-3210.
Bellefontaine A.-F., Pierreux C.E., Mertens P., Vandenhaute J., Letesson J.-J., De Bolle X. Plasticity of transcriptional regulation network among α-Proteobacteria is supported by the identification of CtrA targets in Brucella abortus. Mol. Microbiol. 43(4):2002;945-960.
Boschiroli M.L., Foulongne V., O'Callaghan D. Brucellosis: a worldwide zoonosis. Curr. Opin. Microbiol. 4:2001;58-64.
Boschiroli M.L., Ouahrani-Bettache S., Foulongne V., Michaux-Charachon S., Bourg G., Allardet-Servent A., Cazevieille C., Liautard J.P., Ramuz M., O'Callaghan D. The Brucella suis virB operon is induced intracellularly in macrophages. Proc. Natl. Acad. Sci. U.S.A. 99:2002;1544-1549.
Briones G., Inon de Iannino N., Roset M., Vigliocco A., Paulo P.S., Ugalde R.A. Brucella abortus cyclic β-1,2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells. Infect. Immun. 69:2001;4528-4535.
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., Portetelle D., Puhler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9877-9882.
D'Ari R. Cycle-regulated genes and cell cycle regulation. BioEssays. 23:2001;563-565.
Delrue R.-M., Martinez-Lorenzo M., Lestrate P., Danese I., Bielarz V., Mertens P., De Bolle X., Tibor A., Gorvel J.P., Letesson J.-J. Identification of Brucella spp. genes involved in intracellular trafficking. Cell. Microbiol. 3:2001;487-497.
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N., Overbeek R. The genome sequence of the facultative intracellular pathogen Brucella melitensis. Proc. Natl. Acad. Sci. U.S.A. 99:2002;443-448.
Domian I.J., Reisenauer A., Shapiro L. Feedback control of a master bacterial cell cycle regulator. Proc. Natl. Acad. Sci. U.S.A. 96:1999;6648-6653.
Eskra L., Canavessi A., Carey M., Splitter G. Brucella abortus genes identified following constitutive growth and macrophage infection. Infect. Immun. 69:2001;7736-7742.
Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorholter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puhler A. The complete sequence of the 1683 kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9889-9894.
Fuqua C., Parsek M.R., Greenberg E.P. Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. Annu. Rev. Genet. 35:2001;439-468.
Galibert F., Finan T.M., Long S.R., Puhler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorholter F.J., Weidner S., Wells D.H., Wong K., Yeh K.C., Batut J. The composite genome of the legume symbiont Sinorhizobium meliloti. Science. 293:2001;668-672.
Godfroid F., Taminiau B., Danese I., Denoel P., Tibor A., Weynants V., Cloeckaert A., Godfroid J., Letesson J.-J. Identification of the perosamine synthetase gene of Brucella melitensis 16M and involvement of lipopolysaccharide O side chain in Brucella survival in mice and in macrophages. Infect. Immun. 66:1998;5485-5493.
Godfroid F., Cloeckaert A., Taminiau B., Danese I., Tibor A., De Bolle X., Mertens P., Letesson J.-J. Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of Brucella melitensis 16M (wbk). Res. Microbiol. 151:2000;655-668.
Halling S. On the presence and organization of open reading frames of the non-motile pathogen Brucella abortus similar to class II, III and IV flagellar genes and to LcrD virulence superfamily. Microbial. Comp. Genomics. 3:1998;21-29.
Harshey R.M., Toguchi A. Spinning tails: homologies among bacterial flagellar systems. Trends Microbiol. 4:1996;226-231.
Holden M.T., Ram Chhabra S., de Nys R., Stead P., Bainton N.J., Hill P.J., Manefield M., Kumar N., Labatte M., England D., Rice S., Givskov M., Salmond G.P., Stewart G.S., Bycroft B.W., Kjelleberg S., Williams P. Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria. Mol. Microbiol. 33:1999;1254-1266.
Inon de Iannino N., Briones G., Tolmasky M., Ugalde R. Molecular cloning and characterization of cgs, the Brucella abortus cyclic β-1,2-glucan synthetase gene: genetic complementation of Rhizobium meliloti ndvB and Agrobacterium tumefaciens chvB mutants. J. Bacteriol. 180:1998;4392-4400.
Jenal U. Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control. FEMS Microbiol. Rev. 24:2000;177-191.
Kahng L.S., Shapiro L. The CcrM DNA methyltransferase of Agrobacterium tumefaciens is essential, and its activity is cell cycle regulated. J. Bacteriol. 183:2001;3065-3075.
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res. 7:2000a;331-338.
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res. 7(Suppl.):2000b;381-406.
Köhler S., Ouahrani-Bettache S., Layssac M., Teyssier J., Liautard J.P. Constitutive and inducible expression of green fluorescent protein in Brucella suis. Infect. Immun. 67:1999;6695-6697.
Lang A.S., Beatty J.T. Genetic analysis of a bacterial genetic exchange element: the gene transfer agent of Rhodobacter capsulatus. Proc. Natl. Acad. Sci. U.S.A. 97:2000;859-864.
Laub M.T., McAdams H.H., Feldblyum T., Fraser C.M., Shapiro L. Global analysis of the genetic network controlling a bacterial cell cycle. Science. 290:2000;2144-2148.
Lestrate P., Delrue R.-M., Danese I., Didembourg C., Taminiau B., Mertens P., De Bolle X., Tibor A., Tang C.M., Letesson J.-J. Identification and characterization of in vivo attenuated mutants of Brucella melitensis. Mol. Microbiol. 38:2000;543-551.
LeVier K., Phillips R.W., Grippe V.K., Roop R.M. II, Walker G.C. Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival. Science. 287:2000;2492-2493.
Macnab R., Flagella and motility Neidhardt, F.C. (Ed.), E. coli and Salmonella. Cellular and Molecular Biology. ASM, Washington, pp. 123-145.
Mangan E.K., Malakooti J., Caballero A., Anderson P., Ely B., Gober J.W. FlbT couples flagellum assembly to gene expression in Caulobacter crescentus. J. Bacteriol. 181:1999;6160-6170.
Martin M.E., Brun Y.V. Coordinating development with the cell cycle in Caulobacter. Curr. Opin. Microbiol. 3:2000;589-595.
Moens S., Vanderleyden J. Functions of bacterial flagella. Crit. Rev. Microbiol. 22:1996;67-100.
Moreno E., Moriyon I. Brucella melitensis: a nasty bug with hidden credentials for virulence. Proc. Natl. Acad. Sci. U.S.A. 99:2002;1-3.
Murphy P.J., Heycke N., Trenz S.P., Ratet P., de Bruijn F.J., Schell J. Synthesis of an opine-like compound, a rhizopine, in alfalfa nodules is symbiotically regulated. Proc. Natl. Acad. Sci. U.S.A. 85:1988;9133-9137.
Murphy P.J., Trenz S.P., Grzemski W., De Bruijn F.J., Schell J. The Rhizobium meliloti rhizopine mos locus is a mosaic structure facilitating its symbiotic regulation. J. Bacteriol. 175:1993;5193-5204.
Pesci E.C., Milbank J.B., Pearson J.P., McKnight S., Kende A.S., Greenberg E.P., Iglewski B.H. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A. 96:1999;11229-11234.
Pirhonen M., Flego D., Heikinheimo R., Palva E.T. A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogen Erwinia carotovora. EMBO J. 12:1993;2467-2476.
Platzer J., Sterr W., Hausmann M., Schmitt R. Three genes of a motility operon and their role in flagellar rotary speed variation in Rhizobium meliloti. J. Bacteriol. 179:1997;6391-6399.
Quon K.C., Marczynski G.T., Shapiro L. Cell cycle control by an essential bacterial two-component signal transduction protein. Cell. 84:1996;83-93.
Reisenauer A., Kahng L.S., McCollum S., Shapiro L. Bacterial DNA methylation: a cell cycle regulator? J. Bacteriol. 181:1999;5135-5139.
Robertson G.T., Reisenauer A., Wright R., Jensen R.B., Jensen A., Shapiro L., Roop R.M. II The Brucella abortus CcrM DNA methyltransferase is essential for viability, and its overexpression attenuates intracellular replication in murine macrophages. J. Bacteriol. 182:2000;3482-3489.
Schoenlein P.V., Lui J., Gallman L., Ely B. The Caulobacter crescentus flaFG region regulates synthesis and assembly of flagellin proteins encoded by two genetically unlinked gene clusters. J. Bacteriol. 174:1992;6046-6053.
Sola-Landa A., Pizzaro-Cerda J., Grillo M.-J., Moreno E., Moriyon I., Blasco J.-M., Gorvel J.-P., Lopez-Goni I. A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence. Mol. Microbiol. 29:1998;125-138.
Sourjik V., Sterr W., Platzer J., Bos I., Haslbeck M., Schmitt R. Mapping of 41 chemotaxis, flagellar and motility genes to a single region of the Sinorhizobium meliloti chromosome. Gene. 223:1998;283-290.
Stephens C., Reisenauer A., Wright R., Shapiro L. A cell cycle-regulated bacterial DNA methyltransferase is essential for viability. Proc. Natl. Acad. Sci. U.S.A. 93:1996;1210-1214.
Taminiau B., Daykin M., Swift S., Boschiroli M.L., Tibor A., Lestrate P., De Bolle X., O'Callaghan D., Williams P., Letesson J.-J. Identification of a quorum-sensing signal molecule in the facultative intracellular pathogen Brucella melitensis. Infect. Immun. 70(6):2002;3004-3011.
Tang H.B., DiMango E., Bryan R., Gambello M., Iglewski B.H., Goldberg J.B., Prince A. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect. Immun. 64:1996;37-43.
Volz K. Structural conservation in the CheY superfamily. Biochemistry. 32:1993;11741-11753.
Whitehead N.A., Barnard A.M., Slater H., Simpson N.J., Salmond G.P. Quorum-sensing in Gram-negative bacteria. FEMS Microbiol. Rev. 25:2001;365-404.
Winson M.K., Camara M., Latifi A., Foglino M., Chhabra S.R., Daykin M., Bally M., Chapon V., Salmond G.P., Bycroft B.W. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A. 92:1995;9427-9431.
Wright R., Stephens C., Shapiro L. The CcrM DNA methyltransferase is widespread in the α-subdivision of Proteobacteria, and its essential functions are conserved in Rhizobium meliloti and Caulobacter crescentus. J. Bacteriol. 179:1997;5869-5877.
Young G.M., Schmiel D.H., Miller V.L. A new pathway for the secretion of virulence factors by bacteria: the flagellar export apparatus functions as a protein-secretion system. Proc. Natl. Acad. Sci. U.S.A. 96:1999;6456-6461.