Reference : Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/195898
Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite
English
Ozhukil Kollath, Vinayaraj mailto [> >]
Mullens, Steven mailto []
Luyten, Jan mailto []
Traina, Karl mailto []
Cloots, Rudi mailto [Université de Liège > Département de chimie (sciences) > LCIS - GreenMAT >]
11-Mar-2016
Materials Technology: Advanced Performance Materials
Taylor & Francis
Yes (verified by ORBi)
International
1066-7857
1753-5557
United Kingdom
[en] hydroxyapatite ; dopamine ; protein ; adsorption ; oral delivery ; carrier
[en] Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/195898
10.1179/1753555715Y.0000000048
http://www.tandfonline.com/doi/abs/10.1179/1753555715Y.0000000048

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