Article (Scientific journals)
Reduced dopamine function in depressed patients is related to suicidal behavior but not its lethality
Pitchot, William; Hansenne, Michel; Gonzalez Moreno, A. et al.
2001In Psychoneuroendocrinology, 26 (7), p. 689-696
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Abstract :
[en] Several lines of evidence suggest a role for dopamine in the control of suicidal behaviour. Previously, we suggested an involvement of D2-dopaminergic function in the biology of suicide by demonstrating a smaller growth hormone (GH) response to apomorphine, a dopaminergic agonist, in depressed patients who later died by suicide. The purpose of the present study was to assess GH response to apomorphine in major depressed in-patients with a history of highly lethal suicide attempt compared to depressed patients with a low lethal lifetime suicide attempt history and non-attempters. The study was performed in a sample of 26 male depressed in-patients with a history of suicide attempt compared to 26 male depressed non-attempters. We observed a significant difference between suicide attempters and non-attempters (for GH peak, 6.3+/-5.1 ng/ml vs 15.8+/-14.2 ng/ml, F=10.3, df=1, 50, P=0.002). Moreover, GH peak responses to apomorphine did not differ between depressed patients with a high lethal lifetime suicide attempt history and patients who made low lethal lifetime suicide attempt. In conclusion, the results of the present study support a role for dopamine in the biology of suicidal behaviour. More specifically, an impaired GH response to apomorphine could be a marker of suicide risk.
Disciplines :
Psychiatry
Author, co-author :
Pitchot, William ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Hansenne, Michel  
Gonzalez Moreno, A.
Pinto, Emmanuel ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Reggers, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E
Fuchs, Sonia 
Pirard, Sophie ;  Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Génie catalytique
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Language :
English
Title :
Reduced dopamine function in depressed patients is related to suicidal behavior but not its lethality
Publication date :
October 2001
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Elsevier, United Kingdom
Volume :
26
Issue :
7
Pages :
689-696
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 April 2016

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