Hormonal and temperature responses to the 5-HT1a receptor agonist flesinoxan in normal volunteers

[en] RATIONALE: Flesinoxan is a highly potent and selective 5-HT(1A) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. OBJECTIVES: We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers. METHODS: In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min. RESULTS: Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent. CONCLUSIONS: These results showed the role of 5-HT(1A) mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.

Disciplines :

Psychiatry
Pharmacy, pharmacology & toxicology
Neurosciences & behavior

Author, co-author :

Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Wauthy, Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département d'éducation et formation

Hansenne, Michel

Pinto, Emmanuel ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Fuchs, Sonia

Reggers, Jean ; Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E

Legros, Jean-Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Language :

English

Title :

Hormonal and temperature responses to the 5-HT1a receptor agonist flesinoxan in normal volunteers

Publication date :

October 2002

Journal title :

Psychopharmacology

ISSN :

0033-3158

eISSN :

1432-2072

Publisher :

Springer-Verlag, New York, United States - New York

Volume :

164

Issue :

Pages :

27-32

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 April 2016

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