[en] Integrins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components of the extracellular matrix, and they play an important role in the endometrial phenotype change that occurs during the secretory phase, the first stage of implantation. At the beginning of pregnancy, the change in integrin expression is synchronized with the trophoblast attachment (embryo-endometrium interactions with integrins v3, 41, 61, and 71) and the embryo's invasion of the decidua (integrins 64511141 switch from proliferative to endovascular EVCT). Several diseases, including preeclampsia, intrauterine growth retardation caused by vascular problems and defective luteal phases, may be explained by anomalies in integrin patterns.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Merviel, P.
Challier, J. C.
Carbillon, L.
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Uzan, S.
Language :
English
Title :
The role of integrins in human embryo implantation
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