Article (Scientific journals)
Parallel testing of plasma iron and fibrinogen concentrations to detect systemic inflammation in hospitalized horses.
Corradini, Ignacio; Armengou, Lara; Viu, Judit et al.
2014In Journal of Veterinary Emergency and Critical Care, 24 (4), p. 414-20
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Keywords :
Animals; Fibrinogen/metabolism; Horse Diseases/blood/diagnosis; Horses; Hospitals, Animal; Inflammation/blood/diagnosis/veterinary; Iron/blood; Predictive Value of Tests; Sensitivity and Specificity; biomarkers; equine; inflammatory markers
Abstract :
[en] OBJECTIVES: To determine if plasma iron concentration is different between horses with and without systemic inflammation (SI) and to assess the accuracy for the detection of SI by assaying plasma iron and fibrinogen concentrations, individually or combined. To assess the prognostic value of plasma iron concentration and to describe the progression of plasma iron and fibrinogen concentrations during hospital follow-up, and its relation to SI and survival. DESIGN: Prospective observational study evaluating plasma iron and fibrinogen. SETTING: University veterinary teaching hospital. ANIMALS: Equine patients greater than 30 days of age. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Plasma iron and fibrinogen concentration was prospectively determined in hospitalized horses. Horses were classified into 2 groups: SI and non-SI. Horses were also classified according to clinical outcome. A group of control healthy horses was also included. A total of 135 horses were included in the study. Plasma iron concentration was significantly lower and fibrinogen concentration was higher in the SI group. Nonsurvivors had a mean plasma fibrinogen concentration significantly higher than survivors. The combination of plasma iron and fibrinogen has a high degree of specificity, sensitivity, and accuracy for the detection of SI in horses. Follow-up measurements were obtained in 48 horses. Surviving horses normalized plasma iron concentration during follow-up examination whereas nonsurviving horses had persistently low plasma iron concentrations. CONCLUSIONS: Plasma iron concentration alone is an accurate marker of SI in hospitalized horses. Alteration of both plasma iron and fibrinogen concentrations improves the specificity and positive predictive value for diagnosis of SI. Alteration of either one of both increases sensitivity and negative predictive value. Surviving horses normalized plasma iron concentrations during follow-up period. The combination of plasma iron and fibrinogen concentrations may help in the detection of SI. Follow-up of plasma iron concentrations may provide useful prognostic information.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Corradini, Ignacio
Armengou, Lara
Viu, Judit
Rodriguez-Pozo, Maria L.
Cesarini Latorre, Carlota  ;  Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Jose-Cunilleras, Eduard
Language :
English
Title :
Parallel testing of plasma iron and fibrinogen concentrations to detect systemic inflammation in hospitalized horses.
Publication date :
2014
Journal title :
Journal of Veterinary Emergency and Critical Care
ISSN :
1479-3261
eISSN :
1476-4431
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
24
Issue :
4
Pages :
414-20
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) Veterinary Emergency and Critical Care Society 2014.
Available on ORBi :
since 07 April 2016

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