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hCG: false positives and persistent hCG levels
VALDES SOCIN, Hernan Gonzalo
2016
 

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Keywords :
hCG; persistent levels; false positive
Abstract :
[en] Human Chorionic gonadotropin (hCG) is a complex glycoprotein with several bioactive forms. These five variants comprise placental forms (hyperglycosilated hCG is the first form, then after 10 weeks of pregnancy total hCG takes over), cancer promoter forms (hCGb, hyperglycosilated hCGb), and a pituitary form (sulfated hCG). Current routine laboratory tests do not discriminate between these multiple variants of hCG. Low persistent detectable levels of hCG may be associated with various benign and malignant conditions, such as quiescent gestational trophoblastic disease, raised pituitary hCG, or false positive elevation caused by circulating heterophilic antibodies. Clinico-biological discussion are mandatory to avoid erroneous diagnosis and treatment.In this review we summarize and discuss the different causes of false positive hCG assay. We suggest that current gynecological protocols for the diagnosis and treatment of trophoblastic disease should consider the inclusion of hCG test in urine and/or a test for heterophilic antibodies, when appropriate to avoid unnecessary studies and treatment. References. Valdes Socin H, Syrios P, Gadisseur R, et al. Persistent low levels of hCG: please do not miss phantom hCG! (pseudohypergonadotropinemia syndrome). Acta Clinica Belgica (abstract) 2013;68:465. Cole LA. hCG, the wonder of today’s science. Reprod Biol Endocrinol 2012;10:24–42. B. González Aguilera, P. Syrios, R. Gadisseur, F. Luyckx, E. Cavalier, A. Beckers & H. Valdes-Socin. Persistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease . Gynecological Endocrinology 2016. DOI:10.3109/09513590.2015.1132303
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
VALDES SOCIN, Hernan Gonzalo  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique
Language :
English
Title :
hCG: false positives and persistent hCG levels
Publication date :
29 March 2016
Event name :
Coloquios del Servicio de Endocrinologia
Event organizer :
Prof Graciela Cross. Servicio de Endocrinologia. Hospital de Clinicas Jose de San Martin. Universidad de Buenos Aires
Event place :
Buenos Aires, Argentina
Event date :
29-3-2016
Commentary :
This conference was held as part of an academic cooperation between Facultad de Medicina de Buenos Aires and University of Liege.
Available on ORBi :
since 07 April 2016

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