Article (Scientific journals)
Fetal growth restriction: a workshop report
Cetin, I.; Foidart, Jean-Michel; Miozzo, M. et al.
2004In Placenta, 25 (8-9), p. 753-757
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Abstract :
[en] Intrauterine growth restriction (IUGR) is associated with significantly increased perinatal morbidity and mortality as well as cardiovascular disease and glucose intolerance in adult life. A number of disorders from genetic to metabolic, vascular, coagulative, autoimmune, as well as infectious, can influence fetal growth by damaging the placenta, leading to IUGR as a result of many possible fetal, placental and maternal disorders. Strict definitions of IUGR and of its severity are needed in order to eventually distinguish among different phenotypes, such as gestational age at onset, degree of growth restriction and presence of hypoxia. This report explores and reviews some of the most recent developments in both clinical and basic research on intrauterine growth restriction, by seeking mechanisms that involve genetic factors, utero-placental nutrient availability and vascular growth factors. New exciting findings on the genomic imprinting defects potentially associated with IUGR, and the placental anomalies associated with the decreased nutrient transport are summarized. Moreover, recent data on angiogenic growth factors as well as new information arising from application of gene chip technologies are discussed. (C) 2004 Elsevier Ltd. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Reproductive medicine (gynecology, andrology, obstetrics)
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Cetin, I.;  University of Milano > School of Medicine > Institute of Obstetrics and Gynecology "L. Mangiagalli"
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Miozzo, M.;  University of Milano > Department of Medicine, Surgery and Dentistry > Laboratory of Medical Genetics
Raun, T.;  H:S Hvidovre Hospital (Denmark)
Jansson, T.;  Göteborg University > Department of Physiology and Pharmacology > Perinatal Center
Tsatsaris, V.;  Université Rene Descartes (Paris) > Hôpital Cochin, Maternité Port-Royal > Department of Obstetrics and Gynecology
Reik, W.;  The Babraham Institute (Cambridge, UK) > Developmental Genetics Programme
Cross, J.;  University of Calgary - U of C. > Department of Biochemistry & Molecular Biology > Genes & Development Research Group
Hauguel-de-Mouzon, S.;  Universite Paris 6 > Faculté de Médecine Saint Antoine > UPRESEA 2396
Illsley, N.;  New Jersey Medical School (Newark, NJ) > Department of Obstetrics, Gynecology and Women's Health
Kingdom, J.;  University of Toronto > Mount Sinai Hospital > Maternal-Fetal Medicine Division
Huppertz, B.;  Aachen University > Department of Anatomy
Language :
English
Title :
Fetal growth restriction: a workshop report
Publication date :
2004
Journal title :
Placenta
ISSN :
0143-4004
eISSN :
1532-3102
Publisher :
W.B. Saunders, London, United Kingdom
Volume :
25
Issue :
8-9
Pages :
753-757
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 August 2009

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