ORBi: Cetin I. - Fetal growth restriction: a workshop report

Reference : Fetal growth restriction: a workshop report


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics) Life sciences : Anatomy (cytology, histology, embryology...) & physiology
	To cite this reference:	http://hdl.handle.net/2268/19527

Title :	Fetal growth restriction: a workshop report
Language :	English
Author, co-author :	Cetin, I. [University of Milano > School of Medicine > Institute of Obstetrics and Gynecology "L. Mangiagalli" >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
	Miozzo, M. [University of Milano > Department of Medicine, Surgery and Dentistry > Laboratory of Medical Genetics >]
	Raun, T. [H:S Hvidovre Hospital (Denmark) >]
	Jansson, T. [Göteborg University > Department of Physiology and Pharmacology > Perinatal Center >]
	Tsatsaris, V. [Université Rene Descartes (Paris) > Hôpital Cochin, Maternité Port-Royal > Department of Obstetrics and Gynecology >]
	Reik, W. [The Babraham Institute (Cambridge, UK) > Developmental Genetics Programme >]
	Cross, J. [University of Calgary - U of C. > Department of Biochemistry & Molecular Biology > Genes & Development Research Group >]
	Hauguel-de-Mouzon, S. [Universite Paris 6 > Faculté de Médecine Saint Antoine > UPRESEA 2396 >]
	Illsley, N. [New Jersey Medical School (Newark, NJ) > Department of Obstetrics, Gynecology and Women's Health >]
	Kingdom, J. [University of Toronto > Mount Sinai Hospital > Maternal-Fetal Medicine Division >]
	Huppertz, B. [Aachen University > Department of Anatomy >]
Publication date :	2004
Journal title :	Placenta
Publisher :	W.B. Saunders
Volume :	25
Issue/season :	8-9
Pages :	753-757
ISSN :	0143-4004
City :	London
Country :	United Kingdom
Abstract :	[en] Intrauterine growth restriction (IUGR) is associated with significantly increased perinatal morbidity and mortality as well as cardiovascular disease and glucose intolerance in adult life. A number of disorders from genetic to metabolic, vascular, coagulative, autoimmune, as well as infectious, can influence fetal growth by damaging the placenta, leading to IUGR as a result of many possible fetal, placental and maternal disorders. Strict definitions of IUGR and of its severity are needed in order to eventually distinguish among different phenotypes, such as gestational age at onset, degree of growth restriction and presence of hypoxia. This report explores and reviews some of the most recent developments in both clinical and basic research on intrauterine growth restriction, by seeking mechanisms that involve genetic factors, utero-placental nutrient availability and vascular growth factors. New exciting findings on the genomic imprinting defects potentially associated with IUGR, and the placental anomalies associated with the decreased nutrient transport are summarized. Moreover, recent data on angiogenic growth factors as well as new information arising from application of gene chip technologies are discussed. (C) 2004 Elsevier Ltd. All rights reserved.
Permalink :	http://hdl.handle.net/2268/19527
DOI :	10.1016/j.placenta.2004.02.004

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