Article (Scientific journals)
A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process
Netchacovitch, Lauranne; Thiry, Justine; De Bleye, Charlotte et al.
2016In Talanta, 154, p. 392-399
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Keywords :
Hot-melt extrusion; Film-casting technique; Confocal Raman microscopy; Ultra High Performance Liquid Chromatography; Accuracy profile
Abstract :
[en] When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must be produced and a “reference method” must be used in order to determine the Active Pharmaceutical Ingredient (API) content of each sample. To circumvent this issue, the paper presents a simple approach based on the film-casting technique used as a calibration tool in the framework of hot-melt extrusion process. Confocal Raman microscopic method was successfully validated for the determination of itraconazole content in film-casting samples. Then, hot-melt extrusion was carried out to produce real samples in order to confront the results obtained with confocal Raman microscopy and Ultra High Performance Liquid Chromatography (UHPLC). The agreement between both methods was demonstrated using a comparison study based on the Bland and Altman’s plot.
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Netchacovitch, Lauranne ;  Université de Liège > Département de pharmacie > Chimie analytique
Thiry, Justine ;  Université de Liège > Département de pharmacie > Pharmacie galénique
De Bleye, Charlotte  ;  Université de Liège > Département de pharmacie > Chimie analytique
Dumont, Elodie ;  Université de Liège > Département de pharmacie > Chimie analytique
Dispas, Amandine  ;  Université de Liège > Département de pharmacie > Chimie analytique
Hubert, Cédric  ;  Université de Liège > Département de pharmacie > Chimie analytique
Krier, Fabrice
Sacre, Pierre-Yves  ;  Université de Liège > Département de pharmacie > Chimie analytique
Evrard, Brigitte  ;  Université de Liège > Département de pharmacie > Pharmacie galénique
Hubert, Philippe  ;  Université de Liège > Département de pharmacie > Chimie analytique
Ziemons, Eric  ;  Université de Liège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process
Publication date :
July 2016
Journal title :
Talanta
ISSN :
0039-9140
eISSN :
1873-3573
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
154
Pages :
392-399
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 April 2016

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