Serotonergic modulation of the P300 event related brain potential

While dopaminergic, noradrenergic, cholinergic and gabaergic effects on the P300 component of the human event-related brain potential have been largely described, little is known about serotonergic influence. Therefore, we investigated the relationship between P300 and serotonergic activity as reflected by prolactin (PRL) response to flesinoxan, a 5-HT1A full agonist, among 28 normal subjects. Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.47, p = 0.01 at Cz; r = -0.45, p = 0.01 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin in the neurobiological modulation of P300 amplitude. Clinical implications of these results are considered.

Disciplines :

Psychiatry
Treatment & clinical psychology

Author, co-author :

Hansenne, Michel ; Université de Liège - ULiège > Département de Psychologie > Psycho. de la personnalité et des différences individuelles

PITCHOT, William ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de psychiatrie

Papart, Patrick ; Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale

ANSSEAU, Marc ; Université de Liège - ULg

Language :

English

Title :

Serotonergic modulation of the P300 event related brain potential

Publication date :

1998

Journal title :

Human Psychopharmacology

ISSN :

0885-6222

eISSN :

1099-1077

Publisher :

John Wiley & Sons, Hoboken, United States - New Jersey

Volume :

Issue :

Pages :

239-243

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 July 2021

Statistics

Number of views

82 (10 by ULiège)

Number of downloads

57 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Buhot, M. C. (1997). Serotonin receptors in cognitive behaviors. Current Opinion in Neurobiology, 7, 243-254.
Cassel, J. C. and Jeltsch, H. (1995). Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience, 69, 1-41.
Coccaro, E. F., Gabriel, S. and Siever, L. J. (1990). Buspirone challenge: preliminary evidence for a role for central 5-HT1A receptor function in impulsive aggressive behavior in human. Psychopharmacological Bulletin, 26, 393-405.
Coccaro, E., Siever, L. S., Klar, H. M., Maurer, G., Cochran, K., Cooper, T. B., Mohs, R. C. and Davis, K. L. (1989). Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Archives of General Psychiatry, 46, 587-599.
Donchin, E. and Coles, M. H. G. (1988). Is the P300 component a manifestation of context updating? Brain and Behavioral Science, 11, 357-374.
Groenink, L. and Olivier, B. (1998). Neuroendocrine effects induced by 5-HT1A receptor agonists are mediated centrally, via postsynaptic 5-HT1A receptors. Brain Research, in press.
Hammond, E. J., Meador, K. J., Aung-Din, R. and Wilder, B. K. (1987). Role of the cholinergic system in the generation of human cognitive evoked potentials. Neurology, 37, 346-350.
Hansenne, M., Pitchot, W., Gonzalez Moreno, A., Papart, P., Timsit-Berthier, M. and Ansseau, M. (1995). Catecholaminergic function and P300 amplitude in major depressive disorder (P300 and catecholamines). Electroencephalography and Clinical Neurophysiology, 96, 194-196.
Hansenne, M., Pitchot, W., Gonzalez Moreno, A., Papart, P., Reggers, J., Machurot, P.-Y. and Ansseau, M. (1997). Harm avoidance dimension of the tridimensional personality questionnaire and serotonin-1A activity in depressed patients. Biological Psychiatry, 42, 659-661.
Harder, J. A., Maclean, C. J., Alder, J. T., Francis, P. T. and Ridley, R. M. (1996). The 5-HT1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset. Psychopharmacology, 127, 245-254.
Hasbroucq, T., Rihet, P., Blin, O. and Possamai, C. A. (1997). Serotonin and human information processing: fluvoxamine can improve reaction time performance. Neuroscience Letters, 229, 204-208.
Ito, J., Yamoa, S., Fukuda, H., Mimori, Y. and Nakamura, S. (1990). The P300 event-related potentials in dementia of the Alzheimer type. Correlations between P300 and monoamine metabolites. Electroencephalography and Clinical Neurophysiology, 77, 174-178.
Johnson, R., Jr. (1986). A triarchic model of P300 amplitude. Psychophysiology, 23, 367-384.
Johnson, R., Jr. (1993). On the neural generators of the P300 component of the event-related potential. Psychophysiology, 30, 90-97.
Jonkman, L. M., Kemmer, C., Vertaben, M. N., Koelega, H. S., Camfferman, G., Van der Gaag, R-J., Buitelaar, J. K. and Van Engeland, H. (1997). Effects of methylphenidate on event-related potentials and performance of attention-deficit hyperactivity disorder children in auditory and visual selective attention tasks. Biological Psychiatry, 41, 690-702.
Kutas, M., McCarthy, G. and Donchin, E. (1977). Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. Science, 197, 792-795.
McCarthy, G. and Donchin, E. (1981). A metric for thought: a comparison of P300 latency and reaction time. Science, 211, 77-80.
Meador, K. J. (1995). Cholinergic, serotonergic, and gabaergic effects on the ERP. In Karmos, G., Molnár, M., Csépe, V., Czigler, I. and Desmedt, J. E. (Eds), Perspectives of event-related potentials research, Electroencephalography and Clinical Neurophysiology, Suppl. 44, 151-155.
Meador, K. J., Loring, D. W., Davis, H. C., Setli, K. D., Patel, B. R. and Adams, R. J. (1989). Cholinergic and serotonergic effects on P3 potential and recent memory. Journal of Clinical and Experimental Neuropsychology, 11, 252-260.
New, A. S., Tresman, R. L., Mitropoulou, V., Benishay, D. S., Coccaro, E. F., Silverman, J. and Siever, L. J. (1997). Serotonin function and self-injurious behavior in personality disorder patients. Psychiatry Research, 69, 17-26.
Picton, T. W. (1992). The P300 wave of the human event-related potential. Journal of Clinical Neurophysiology, 9, 456-479.
Pitchot, W., Ansseau, M., Gonzalez Moreno, A., Lembreghts, M., Hansenne, M., Wauthy, J., Reel, C., Jammaer, R., Papart, P., Sulon, J. and Legros, J-J. (1995). The flesinoxan 5-HT1A receptor challenge test in major depression and suicidal behavior. Pharmacopsychiatry, 28, 91-92.
Polich, J. (1991). P300 in the evaluation of aging and dementia. In Brunia, C. H. M., Mulder, G. and Vertaben, M. N. (Eds), Event-related brain research, Electroencepholagraphy and Clinical Neurophysiology, Suppl. 42, 304-323.
Pritchard, W. S., Raz, N. and August, G. J. (1986). Brief report: No effect of chronic fenfluramine on the P300 component of the event-related potential. International Journal of Neuroscience, 35, 105-110.
Raine, A. and Venables, P. H. (1988). Enhanced P3 evoked potentials and longer recovery times in psychopaths. Psychophysiology, 25, 30-38.
Semlitsch, H. V., Anderer, P. and Saletu, B. (1995). Acute effects of the anxiolytics suriclone and alprazolam on cognitive processing utilizing topographic mapping of event-related brain potentials (P300) in healthy subjects. European Journal of Clinical Pharmacology, 49, 183-191.
Smulders, F. T. Y., Kok, A., Kenemans, J. L. and Bashore, T. R. (1995). The temporal selectivity of additive factor effects on the reaction process revealed in ERP component latencies. Acta Psychologica, 90, 97-109.
Sommer, W. and Matt, J. (1990). Awareness of P300-related cognitive processes: a signal detection approach. Psychophysiology, 27, 575-585.
Swick, D., Pineda, A. and Foote, S. L. (1994). Effects of systematic clonidine on auditory event-related potentials in squirrel monkeys. Brain Research Bulletin, 33, 79-86.
Verleger, R. (1988). Event-related potentials and cognition: a critique of the context updating hypothesis and an alternative interpretation of P3. Behavioral and Brain Sciences, 11, 343-356.