Impact of feeding and housing on the development ofosteochondrosis in foals—A longitudinal study

[en] Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of osteochondral fragments in the articulation, fissures or subchondral bone cysts in the growth cartilage. Occurrence of osteochondrosis is influenced by a complex interaction of different factors. Among these, the effect of the housing and the feeding of the foals during their first months of life, have been described as risk factors for the development of osteochondrosis. The aim of this study was to investigate the evolution of OCD lesions with a longitudinal study in 204 young foals from 6 to 18 months in comparison to the type of feeding and the type of housing conditions. These factors and OCD status were obtained by a questionnaire and radiological examination, respectively. This allowed dividing the foals into four groups according to the initial OCD status and the evolution of the condition. As a result, we found that foals fed with concentrates show a higher probability to develop OCD lesions (p = 0.06), while foals not receiving concentrates, had a higher probability to heal from existing OCD lesions (p = 0.001). This study supports the theory that management factors such as feeding or housing may influence the evolution of the osteochondrosis disease.

Research center :

Centre Européen du Cheval de Mont-Le-Soie

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Mendoza García, Luis ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Lejeune, Jean-Philippe ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Caudron, Isabelle ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Dép. clinique des animaux de compagnie et des équidés (DCA)

Detilleux, Johann ; Université de Liège > Département des productions animales (DPA) > Génétique quantitative

Sandersen, Charlotte ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires

Deliège, Brigitte

Serteyn, Didier ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Language :

English

Title :

Impact of feeding and housing on the development ofosteochondrosis in foals—A longitudinal study

Publication date :

2016

Journal title :

Preventive Veterinary Medicine

ISSN :

0167-5877

eISSN :

1873-1716

Publisher :

Elsevier Scientific, Amsterdam, Netherlands

Volume :

127

Pages :

10-14

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science/article/pii/S0167587716300848

Available on ORBi :

since 21 March 2016

Statistics

Number of views

64 (12 by ULiège)

Number of downloads

5 (5 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Arnaud, G., Dubroeucq, H., Rivot, D., (1997) Notation De l'état Corporel Des Chevaux De Selle Et De Sport: Guide Pratique, , Institut de l'élevage, Paris
Demidenko, E., Sample size determination for logistic regression revisited (2007) Stat. Med., 26, pp. 3385-3397
Denoix, J.M., Jacquet, S., Lepeule, J., Crevier-Denoix, N., Valette, J.P., Robert, C., Radiographic findings of juvenile osteochondral conditions detected in 392 foals using a field radiographic protocol (2013) Vet. J., 197, pp. 44-51
Donabédian, M., Fleurance, G., Perona, G., Robert, C., Lepage, O., Trillaud-Geyl, C., Leger, S., Martin-Rosset, W., Effect of fast vs moderate growth rate related to nutrient intake on developmental orthopaedic disease in the horse (2006) Anim. Res., 55, pp. 471-486
Faul, F., Erdfelder, E., Buchner, A., Lang, A.G., Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses (2009) Behav. Res. Methods, 41, pp. 1149-1160
Garcia-Martin, A., Rozas-Moreno, P., Reyes-Garcia, R., Morales-Santana, S., Garcia-Fontana, B., Garcia-Salcedo, J.A., Munoz-Torres, M., Circulating levels of sclerostin are increased in patients with type 2 diabetes mellitus (2012) J. Clin. Endocrinol. Metab., 97, pp. 234-241
Hilla, D., Distl, O., Heritabilities and genetic correlations between fetlock, hock and stifle osteochondrosis and fetlock osteochondral fragments in Hanoverian Warmblood horses (2013) J. Anim. Breed. Genet., 131, pp. 71-81
Jacquet, S., Robert, C., Valette, J.P., Denoix, J.M., Evolution of radiological findings detected in the limbs of 321 young horses between the ages of 6 and 18 months (2013) Vet. J., 197, pp. 58-64
Jeffcott, L.B., Osteochondrosis in the horse-searching for the key to pathogenesis (1991) Equine Vet. J., 23, pp. 331-338
Laverty, S., Girard, C., Pathogenesis of epiphyseal osteochondrosis (2013) Vet. J., 197, pp. 3-12
Lecocq, M., Girard, C.A., Fogarty, U., Beauchamp, G., Richard, H., Laverty, S., Cartilage matrix changes in the developing epiphysis: early events on the pathway to equine osteochondrosis? (2008) Equine Vet. J., 40, pp. 442-454
Lepeule, J., Bareille, N., Robert, C., Ezanno, P., Valette, J.P., Jacquet, S., Blanchard, G., Seegers, H., Association of growth, feeding practices and exercise conditions with the prevalence of Developmental Orthopaedic Disease in limbs of French foals at weaning (2009) Prev. Vet. Med., 89, pp. 167-177
Lepeule, J., Bareille, N., Robert, C., Valette, J.P., Jacquet, S., Blanchard, G., Denoix, J.M., Seegers, H., Association of growth, feeding practices and exercise conditions with the severity of the osteoarticular status of limbs in French foals (2013) Vet. J., 197, pp. 65-71
Lykkjen, S., Roed, K.H., Dolvik, N.I., Osteochondrosis and osteochondral fragments in Standardbred trotters: prevalence and relationships (2012) Equine Vet. J., 44, pp. 332-338
Mendoza, L., Piquemal, D., Lejeune, J.-P., Vander Heyden, L., Noguier, F., Bruno, R., Sandersen, C., Serteyn, D., Age-dependent expression of osteochondrosis-related genes in equine leukocytes (2015) Vet. Rec. Open, 2
McIlwraith, C.W., Inferences from referred clinical cases of osteochondritis dissecans (1993) Equine Vet. J., 25, pp. 27-30
Mirams, M., Tatarczuch, L., Ahmed, Y.A., Pagel, C.N., Jeffcott, L.B., Davies, H.M., Mackie, E.J., Altered gene expression in early osteochondrosis lesions (2009) J. Orthopaedic Res., 27, pp. 452-457
Nixon, A.J., Pool, R.R., Histologic appearance of axial osteochondral fragments from the proximoplantar/proximopalmar aspect of the proximal phalanx in horses (1995) J. Am. Vet. Med. Assoc., 207, pp. 1076-1080
Power, J., Hernandez, P., Wardale, J., Henson, F.M.D., Alterations in sclerostin protein in lesions of equine osteochondrosis (2014) Vet. Rec. Open, 1. , e000005-e000005
Rejno, S., Stromberg, B., Osteochondrosis in the horse: II. Pathology (1978) Acta Radiol. Suppl., 358, pp. 153-178
Riddick, T.L., Duesterdieck-Zellmer, K., Semevolos, S.A., Gene and protein expression of cartilage canal and osteochondral junction chondrocytes and full-thickness cartilage in early equine osteochondrosis (2012) Vet. J., 194, pp. 319-325
Robert, C., Valette, J.P., Jacquet, S., Lepeule, J., Denoix, J.M., Study design for the investigation of likely aetiological factors of juvenile osteochondral conditions (JOCC) in foals and yearlings (2013) Vet. J., 197, pp. 36-43
Savage, C.J., McCarthy, R.N., Jeffcott, L.B., Effects of dietary energy and protein on induction of dyschondroplasia in foals (1993) Equine Vet. J., 25, pp. 74-79
Semevolos, S.A., Brower-Toland, B.D., Bent, S.J., Nixon, A.J., Parathyroid hormone-related peptide and indian hedgehog expression patterns in naturally acquired equine osteochondrosis (2002) J. Orthop. Res., 20, pp. 1290-1297
Semevolos, S.A., Strassheim, M.L., Haupt, J.L., Nixon, A.J., Expression patterns of hedgehog signaling peptides in naturally acquired equine osteochondrosis (2005) J. Orthop. Res., 23, pp. 1152-1159
Serteyn, D., Piquemal, D., Vanderheyden, L., Lejeune, J.P., Verwilghen, D., Sandersen, C., Gene expression profiling from leukocytes of horses affected by osteochondrosis (2010) J. Orthop. Res., 28, pp. 965-970
Serteyn, D., Mendoza, L., Sandersen, C., Caudron, I., Piquemal, D., Chavatte-Palmer, P., Lejeune, J.-P., High plasma concentrations of sclerostin, an inhibitor of the wnt signaling pathway, in young horses affected by osteochondrosis (2014) Open J. Orthop., 4, pp. 335-342
Vander Heyden, L., Serteyn, D., Caudron, I., Verwilghen, D., deliege, B., Lejeune, J.P., Prévalence de l'ostéochondrose chez le cheval de sport en Wallonie (2008) Ann. Med. Vet., 152, pp. 61-70
Vander Heyden, L., Lejeune, J.P., Caudron, I., Detilleux, J., Sandersen, C., Chavatte, P., Paris, J., Serteyn, D., Association of breeding conditions with prevalence of osteochondrosis in foals (2013) Vet. Rec., 172, p. 68
Verwilghen, D.R., Janssens, S., Busoni, V., Pille, F., Johnston, C., Serteyn, D., Do developmental orthopaedic disorders influence future jumping performances in Warmblood stallions? (2013) Equine Vet. J., 45, pp. 578-581
Vos, N.J., Incidence of osteochondrosis (dissecans) in Dutch warmblood horses presented for pre-purchase examination (2008) Ir. Vet. J., 61, pp. 33-37
Ytrehus, B., Carlson, C.S., Ekman, S., Etiology and pathogenesis of osteochondrosis (2007) Vet. Pathol., 44, pp. 429-448
van Weeren, P.R., Denoix, J.M., The Normandy field study on juvenile osteochondral conditions: conclusions regarding the influence of genetics, environmental conditions and management, and the effect on performance (2013) Vet. J., 197, pp. 90-95