Article (Scientific journals)
Linking flowability and granulometry of lactose powders
Boschini, Frédéric; Delaval, Vincent; Traina, Karl et al.
2015In International Journal of Pharmaceutics
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Keywords :
Lactose; flowability; rheology; Packing fraction; cohesion
Abstract :
[en] The flowing properties of 10 lactose powders commonly used in pharmaceutical industries have been analyzed with three recently improved measurement methods. The first method is based on the heap shape measurement. This straightforward measurement method provides two physical parameters (angle of repose αr and static cohesive index σr) allowing to make a first screening of the powder properties. The second method allows to estimate the rheological properties of a powder by analyzing the powder flow in a rotating drum. This more advanced method gives a large set of physical parameters (flowing angle αf, dynamic cohesive index σf, angle of first avalanche αa and powder aeration %ae) leading to deeper interpretations. The third method is an improvement of the classical bulk and tapped density measurements. In addition to the improvement of the measurement precision, the densification dynamics of the powder bulk submitted to taps is analyzed. The link between the macroscopic physical parameters obtained with these methods and the powder granulometry is analyzed. Moreover, the correlations between the different flowability indexes are discussed. Finally, the link between grain shape and flowability is discussed qualitatively.
Research center :
APTIS
Disciplines :
Physics
Author, co-author :
Boschini, Frédéric ;  Université de Liège > Plateforme APTIS
Delaval, Vincent ;  Université de Liège > Département de physique > Physique statistique
Traina, Karl ;  Université de Liège - ULiège > Département de chimie (sciences) > LCIS - GreenMAT
Vandewalle, Nicolas  ;  Université de Liège > Département de physique > Physique statistique
Lumay, Geoffroy ;  Université de Liège > Département de physique > Physique expér. de la matière molle et des syst. complexes
Language :
English
Title :
Linking flowability and granulometry of lactose powders
Publication date :
2015
Journal title :
International Journal of Pharmaceutics
ISSN :
0378-5173
eISSN :
1873-3476
Publisher :
Elsevier Science, Amsterdam, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 March 2016

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