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| Reference : Neutralization of Bovine Herpesvirus Type 4 by Pairs of Monoclonal Antibodies Raised aga... |
| Scientific journals : Article | |||
| Life sciences : Microbiology Life sciences : Veterinary medicine & animal health | |||
| http://hdl.handle.net/2268/19398 | |||
| Neutralization of Bovine Herpesvirus Type 4 by Pairs of Monoclonal Antibodies Raised against Two Glycoproteins and Identification of Antigenic Determinants Involved in Neutralization | |
| English | |
| Dubuisson, J. [> > > >] | |
| Guillaume, José [ > > ] | |
| Boulanger, D. [> > > >] | |
Thiry, Etienne  [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >] | |
| Bublot, M. [> > > >] | |
| Pastoret, Paul-Pierre [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Département des maladies infectieuses et parasitaires >] | |
| Mar-1990 | |
| Journal of General Virology (The) | |
| 71 | |
| (Pt 3) | |
| 647-53 | |
| International | |
| 0022-1317 | |
| [en] In infected cattle, bovine herpesvirus type 4 (BHV-4) induces an immune response with low neutralizing antibody levels or in the absence of such antibodies. For the study of this phenomenon, monoclonal antibodies (MAbs) raised against two BHV-4 glycoproteins identified previously (150K/120K/51K and 120K/16.5K) were used in neutralization tests. None of the MAbs except for MAb 16 could neutralize alone; pairs of MAbs against the 150K/120K/51K and 120K/16.5K glycoproteins were able to neutralize BHV-4 infectivity. MAbs involved in neutralization were used in competitive binding assays to identify epitopes relevant for BHV-4 neutralization. These MAbs showed a low avidity and a weak neutralizing activity, and they partially decreased BHV-4 attachment to cells. These results suggest that the BHV-4 glycoprotein domains involved in viral infectivity are poorly exposed to the immune system. | |
| http://hdl.handle.net/2268/19398 |
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