Reference : Frontal and posterior cingulate metabolic impairment in the behavioural variant of front...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/19361
Frontal and posterior cingulate metabolic impairment in the behavioural variant of frontotemporal dementia with impaired autonoetic consciousness
English
Bastin, Christine mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Feyers, Dorothée mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron > > >]
Souchay, Céline mailto [ > > ]
Guillaume, Bénédicte mailto [ > > ]
Pepin, Jean-Louis mailto [Université de Liège - ULg > > Neurologie CHR >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives / Centre de Recherches du Cyclotron > > >]
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron / Département des sciences cliniques > > >]
2012
Human Brain Mapping
Wiley Liss, Inc.
33
1268-1278
Yes (verified by ORBi)
International
1065-9471
1097-0193
New York
NY
[en] frontotemporal dementia ; episodic memory ; autonoetic consciousness ; monitoring ; FOK ; FDG-PET ; cingulate cortex
[en] Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling-of-knowing (FOK) in bv-FTD. Analyses of the patients’ cerebral metabolism (FDG-PET) allowed an examination of whether impaired episodic memory in bv-FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory-specific regions pertaining to Papez’s circuit. Data were obtained from 8 bv-FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv-FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (7) patients, 4 bv-FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self-referential processes, suggesting that the bv-FTD patients’ problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self.
Centre de Recherches du Cyclotron - CRC
Inter-University Attraction Pole [grant number P6/29] ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Université de Liège ; European Community projects Nest-DD and EC – FP6-project DiMI [LSHB-CT-2005-512146]
Researchers
http://hdl.handle.net/2268/19361

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