Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading?
[en] The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, urgent, and emergency settings. The 2014 document updates and extends the effort started in 2010, year of the first edition of these guidelines. Importantly, this latest edition provides a systematic review of all randomized clinical trials performed since 1980, comparing different strategies of myocardial revascularization, including coronary artery bypass graft (CABG), balloon angioplasty, percutaneous coronary intervention (PCI) with bare-metal stents (BMS) and first- and second-generation drug-eluting stents (DES). This review aims to highlight the most relevant novelties introduced by the 2014 edition of the ESC/EACTS myocardial revascularization guidelines as compared with the previous edition and to describe similarities and differences with the American societies' guidelines.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Costa, Francesco
Ariotti, Sara
Valgimigli, Marco
Kolh, Philippe ; Université de Liège - ULiège > Département des Sciences biomédicales et précliniques > Service de Biochimie et de Physiologie humaines, normale et pathologique
Windecker, Stephan
Language :
English
Title :
Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading?
Head, S. J., Kieser, T. M., Falk, V., Huysmans, H. A., & Kappetein, A. P. (2013). Coronary artery bypass grafting: part 1—the evolution over the first 50 years. European Heart Journal, 34(37), 2862–2872. doi:10.1093/eurheartj/eht330.
Windecker, S., Kolh, P., Alfonso, F., Collet, J. P., Cremer, J., Falk, V., Filippatos, G., Hamm, C., Head, S. J., Juni, P., Kappetein, A. P., Kastrati, A., Knuuti, J., Landmesser, U., Laufer, G., Neumann, F. J., Richter, D. J., Schauerte, P., Sousa Uva, M., Stefanini, G. G., Taggart, D. P., Torracca, L., Valgimigli, M., Wijns, W., Witkowski, A., & Authors/Task Force m. (2014). 2014 ESC/EACTS guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal, 35(37), 2541–2619. doi:10.1093/eurheartj/ehu278.
Task Force on Myocardial Revascularization of the European Society of Cardiology, the European Association for Cardio-Thoracic Surgery, European Association for Percutaneous Cardiovascular Intervention, Wijns, W., Kolh, P., Danchin, N., Di Mario, C., Falk, V., Folliguet, T., Garg, S., Huber, K., James, S., Knuuti, J., Lopez-Sendon, J., Marco, J., Menicanti, L., Ostojic, M., Piepoli, M. F., Pirlet, C., Pomar, J. L., Reifart, N., Ribichini, F. L., Schalij, M. J., Sergeant, P., Serruys, P. W., Silber, S., Sousa Uva, M., & Taggart, D. (2010). Guidelines on myocardial revascularization. European Heart Journal, 31(20), 2501–2555. doi:10.1093/eurheartj/ehq277.
Levine, G. N., Bates, E. R., Blankenship, J. C., Bailey, S. R., Bittl, J. A., Cercek, B., Chambers, C. E., Ellis, S. G., Guyton, R. A., Hollenberg, S. M., Khot, U. N., Lange, R. A., Mauri, L., Mehran, R., Moussa, I. D., Mukherjee, D., Nallamothu, B. K., & Ting, H. H. (2011). 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation, 124(23), e574–651. doi:10.1161/CIR.0b013e31823ba622.
Hillis, L. D., Smith, P. K., Anderson, J. L., Bittl, J. A., Bridges, C. R., Byrne, J. G., Cigarroa, J. E., Disesa, V. J., Hiratzka, L. F., Hutter, A. M., Jr., Jessen, M. E., Keeley, E. C., Lahey, S. J., Lange, R. A., London, M. J., Mack, M. J., Patel, M. R., Puskas, J. D., Sabik, J. F., Selnes, O., Shahian, D. M., Trost, J. C., & Winniford, M. D. (2011). 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 124(23), 2610–2642. doi:10.1161/CIR.0b013e31823b5fee.
Fihn, S. D., Gardin, J. M., Abrams, J., Berra, K., Blankenship, J. C., Dallas, A. P., Douglas, P. S., Foody, J. M., Gerber, T. C., Hinderliter, A. L., King, S. B., 3rd, Kligfield, P. D., Krumholz, H. M., Kwong, R. Y., Lim, M. J., Linderbaum, J. A., Mack, M. J., Munger, M. A., Prager, R. L., Sabik, J. F., Shaw, L. J., Sikkema, J. D., Smith, C. R., Jr., Smith, S. C., Jr., Spertus, J. A., Williams, S. V., Anderson, J. L., & American College of Cardiology Foundation/American Heart Association Task F. (2012). 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation, 126(25), e354–471. doi:10.1161/CIR.0b013e318277d6a0.
O’Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Jr., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., Granger, C. B., Krumholz, H. M., Linderbaum, J. A., Morrow, D. A., Newby, L. K., Ornato, J. P., Ou, N., Radford, M. J., Tamis-Holland, J. E., Tommaso, C. L., Tracy, C. M., Woo, Y. J., Zhao, D. X., Anderson, J. L., Jacobs, A. K., Halperin, J. L., Albert, N. M., Brindis, R. G., Creager, M. A., DeMets, D., Guyton, R. A., Hochman, J. S., Kovacs, R. J., Kushner, F. G., Ohman, E. M., Stevenson, W. G., Yancy, C. W., & American College of Cardiology Foundation/American Heart Association Task Force on Practice G. (2013). 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 127(4), e362–425. doi:10.1161/CIR.0b013e3182742cf6.
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Jr., Ganiats, T. G., Holmes, D. R., Jr., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., Levine, G. N., Liebson, P. R., Mukherjee, D., Peterson, E. D., Sabatine, M. S., Smalling, R. W., & Zieman, S. J. (2014). 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, 130(25), 2354–2394. doi:10.1161/CIR.0000000000000133.
Fihn, S. D., Blankenship, J. C., Alexander, K. P., Bittl, J. A., Byrne, J. G., Fletcher, B. J., Fonarow, G. C., Lange, R. A., Levine, G. N., Maddox, T. M., Naidu, S. S., Ohman, E. M., & Smith, P. K. (2014). 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation, 130(19), 1749–1767. doi:10.1161/CIR.0000000000000095.
Farooq, V., van Klaveren, D., Steyerberg, E. W., Meliga, E., Vergouwe, Y., Chieffo, A., Kappetein, A. P., Colombo, A., Holmes, D. R., Jr., Mack, M., Feldman, T., Morice, M. C., Stahle, E., Onuma, Y., Morel, M. A., Garcia-Garcia, H. M., van Es, G. A., Dawkins, K. D., Mohr, F. W., & Serruys, P. W. (2013). Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II. Lancet, 381(9867), 639–650. doi:10.1016/S0140-6736(13)60108-7.
Morice, M. C., Serruys, P. W., Kappetein, A. P., Feldman, T. E., Stahle, E., Colombo, A., Mack, M. J., Holmes, D. R., Torracca, L., van Es, G. A., Leadley, K., Dawkins, K. D., & Mohr, F. (2010). Outcomes in patients with de novo left main disease treated with either percutaneous coronary intervention using paclitaxel-eluting stents or coronary artery bypass graft treatment in the Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX) trial. Circulation, 121(24), 2645–2653. doi:10.1161/CIRCULATIONAHA.109.899211.
Park, S. J., Kim, Y. H., Park, D. W., Yun, S. C., Ahn, J. M., Song, H. G., Lee, J. Y., Kim, W. J., Kang, S. J., Lee, S. W., Lee, C. W., Park, S. W., Chung, C. H., Lee, J. W., Lim, D. S., Rha, S. W., Lee, S. G., Gwon, H. C., Kim, H. S., Chae, I. H., Jang, Y., Jeong, M. H., Tahk, S. J., & Seung, K. B. (2011). Randomized trial of stents versus bypass surgery for left main coronary artery disease. The New England Journal of Medicine, 364(18), 1718–1727. doi:10.1056/NEJMoa1100452.
Blazek, S., Holzhey, D., Jungert, C., Borger, M. A., Fuernau, G., Desch, S., Eitel, I., de Waha, S., Lurz, P., Schuler, G., Mohr, F. W., & Thiele, H. (2013). Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: 10-year follow-up of a randomized trial. JACC: Cardiovascular Interventions, 6(1), 20–26. doi:10.1016/j.jcin.2012.09.008.
Mohr, F. W., Morice, M. C., Kappetein, A. P., Feldman, T. E., Stahle, E., Colombo, A., Mack, M. J., Holmes, D. R., Jr., Morel, M. A., Van Dyck, N., Houle, V. M., Dawkins, K. D., & Serruys, P. W. (2013). Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial. Lancet, 381(9867), 629–638. doi:10.1016/S0140-6736(13)60141-5.
Farkouh, M. E., Domanski, M., Sleeper, L. A., Siami, F. S., Dangas, G., Mack, M., Yang, M., Cohen, D. J., Rosenberg, Y., Solomon, S. D., Desai, A. S., Gersh, B. J., Magnuson, E. A., Lansky, A., Boineau, R., Weinberger, J., Ramanathan, K., Sousa, J. E., Rankin, J., Bhargava, B., Buse, J., Hueb, W., Smith, C. R., Muratov, V., Bansilal, S., King, S., 3rd, Bertrand, M., Fuster, V., & Investigators FT. (2012). Strategies for multivessel revascularization in patients with diabetes. The New England Journal of Medicine, 367(25), 2375–2384. doi:10.1056/NEJMoa1211585.
Head, S. J., Davierwala, P. M., Serruys, P. W., Redwood, S. R., Colombo, A., Mack, M. J., Morice, M. C., Holmes, D. R., Jr., Feldman, T. E., Stahle, E., Underwood, P., Dawkins, K. D., Kappetein, A. P., & Mohr, F. W. (2014). Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year follow-up of the SYNTAX trial. European Heart Journal, 35(40), 2821–2830. doi:10.1093/eurheartj/ehu213.
Verma, S., Farkouh, M. E., Yanagawa, B., Fitchett, D. H., Ahsan, M. R., Ruel, M., Sud, S., Gupta, M., Singh, S., Gupta, N., Cheema, A. N., Leiter, L. A., Fedak, P. W., Teoh, H., Latter, D. A., Fuster, V., & Friedrich, J. O. (2013). Comparison of coronary artery bypass surgery and percutaneous coronary intervention in patients with diabetes: a meta-analysis of randomised controlled trials. The Lancet Diabetes & Endocrinology, 1(4), 317–328. doi:10.1016/S2213-8587(13)70089-5.
Sajja, L. R., Mannam, G., Chakravarthi, R. M., Sompalli, S., Naidu, S. K., Somaraju, B., & Penumatsa, R. R. (2007). Coronary artery bypass grafting with or without cardiopulmonary bypass in patients with preoperative non-dialysis dependent renal insufficiency: a randomized study. The Journal of Thoracic and Cardiovascular Surgery, 133(2), 378–388. doi:10.1016/j.jtcvs.2006.09.028.
Li, Y., Liu, Y., Fu, L., Mei, C., & Dai, B. (2012). Efficacy of short-term high-dose statin in preventing contrast-induced nephropathy: a meta-analysis of seven randomized controlled trials. PLoS One, 7(4), e34450. doi:10.1371/journal.pone.0034450.
Bellemain-Appaix, A., O’Connor, S. A., Silvain, J., Cucherat, M., Beygui, F., Barthelemy, O., Collet, J. P., Jacq, L., Bernasconi, F., Montalescot, G., & Group A. (2012). Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. JAMA, 308(23), 2507–2516. doi:10.1001/jama.2012.50788.
Valgimigli, M., Campo, G., Monti, M., Vranckx, P., Percoco, G., Tumscitz, C., Castriota, F., Colombo, F., Tebaldi, M., Fuca, G., Kubbajeh, M., Cangiano, E., Minarelli, M., Scalone, A., Cavazza, C., Frangione, A., Borghesi, M., Marchesini, J., Parrinello, G., Ferrari, R., & Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia Study I. (2012). Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial. Circulation, 125(16), 2015–2026. doi:10.1161/CIRCULATIONAHA.111.071589.
Gwon, H. C., Hahn, J. Y., Park, K. W., Song, Y. B., Chae, I. H., Lim, D. S., Han, K. R., Choi, J. H., Choi, S. H., Kang, H. J., Koo, B. K., Ahn, T., Yoon, J. H., Jeong, M. H., Hong, T. J., Chung, W. Y., Choi, Y. J., Hur, S. H., Kwon, H. M., Jeon, D. W., Kim, B. O., Park, S. H., Lee, N. H., Jeon, H. K., Jang, Y., & Kim, H. S. (2012). Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) randomized, multicenter study. Circulation, 125(3), 505–513. doi:10.1161/CIRCULATIONAHA.111.059022.
Montalescot, G., Bolognese, L., Dudek, D., Goldstein, P., Hamm, C., Tanguay, J. F., ten Berg, J. M., Miller, D. L., Costigan, T. M., Goedicke, J., Silvain, J., Angioli, P., Legutko, J., Niethammer, M., Motovska, Z., Jakubowski, J. A., Cayla, G., Visconti, L. O., Vicaut, E., Widimsky, P., & Investigators, A. (2013). Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes. The New England Journal of Medicine, 369(11), 999–1010. doi:10.1056/NEJMoa1308075.
Zeymer, U., Arntz, H. R., Mark, B., Fichtlscherer, S., Werner, G., Scholler, R., Zahn, R., Diller, F., Darius, H., Dill, T., & Huber, K. (2012). Efficacy and safety of a high loading dose of clopidogrel administered prehospitally to improve primary percutaneous coronary intervention in acute myocardial infarction: the randomized CIPAMI trial. Clinical Research in Cardiology: Official Journal of the German Cardiac Society, 101(4), 305–312. doi:10.1007/s00392-011-0393-1.
Koul, S., Smith, J. G., Schersten, F., James, S., Lagerqvist, B., & Erlinge, D. (2011). Effect of upstream clopidogrel treatment in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. European Heart Journal, 32(23), 2989–2997. doi:10.1093/eurheartj/ehr202.
Dorler, J., Edlinger, M., Alber, H. F., Altenberger, J., Benzer, W., Grimm, G., Huber, K., Pachinger, O., Schuchlenz, H., Siostrzonek, P., Zenker, G., Weidinger, F., & Austrian Acute PCII. (2011). Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction. European Heart Journal, 32(23), 2954–2961. doi:10.1093/eurheartj/ehr360.
Shahzad, A., Kemp, I., Mars, C., Wilson, K., Roome, C., Cooper, R., Andron, M., Appleby, C., Fisher, M., Khand, A., Kunadian, B., Mills, J. D., Morris, J. L., Morrison, W. L., Munir, S., Palmer, N. D., Perry, R. A., Ramsdale, D. R., Velavan, P., Stables, R. H., & Investigators H-Pt. (2014). Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial. Lancet, 384(9957), 1849–1858. doi:10.1016/S0140-6736(14)60924-7.
Stone, G. W., McLaurin, B. T., Cox, D. A., Bertrand, M. E., Lincoff, A. M., Moses, J. W., White, H. D., Pocock, S. J., Ware, J. H., Feit, F., Colombo, A., Aylward, P. E., Cequier, A. R., Darius, H., Desmet, W., Ebrahimi, R., Hamon, M., Rasmussen, L. H., Rupprecht, H. J., Hoekstra, J., Mehran, R., Ohman, E. M., & Investigators A. (2006). Bivalirudin for patients with acute coronary syndromes. The New England Journal of Medicine, 355(21), 2203–2216. doi:10.1056/NEJMoa062437.
Kastrati, A., Neumann, F. J., Schulz, S., Massberg, S., Byrne, R. A., Ferenc, M., Laugwitz, K. L., Pache, J., Ott, I., Hausleiter, J., Seyfarth, M., Gick, M., Antoniucci, D., Schomig, A., Berger, P. B., Mehilli, J., & Investigators I-RT. (2011). Abciximab and heparin versus bivalirudin for non-ST-elevation myocardial infarction. The New England Journal of Medicine, 365(21), 1980–1989. doi:10.1056/NEJMoa1109596.
Valgimigli, M., & Investigators M. (2014). Design and rationale for the Minimizing Adverse haemorrhagic events by TRansradial access site and systemic Implementation of angioX program. American Heart Journal, 168(6), 838–845. doi:10.1016/j.ahj.2014.08.013. e836.
Mega, J. L., Braunwald, E., Wiviott, S. D., Bassand, J. P., Bhatt, D. L., Bode, C., Burton, P., Cohen, M., Cook-Bruns, N., Fox, K. A., Goto, S., Murphy, S. A., Plotnikov, A. N., Schneider, D., Sun, X., Verheugt, F. W., Gibson, C. M., & Investigators AAT. (2012). Rivaroxaban in patients with a recent acute coronary syndrome. The New England Journal of Medicine, 366(1), 9–19. doi:10.1056/NEJMoa1112277.
Windecker, S., Stortecky, S., Stefanini, G. G., da Costa, B. R., Rutjes, A. W., Di Nisio, M., Silletta, M. G., Maione, A., Alfonso, F., Clemmensen, P. M., Collet, J. P., Cremer, J., Falk, V., Filippatos, G., Hamm, C., Head, S., Kappetein, A. P., Kastrati, A., Knuuti, J., Landmesser, U., Laufer, G., Neumann, F. J., Richter, D., Schauerte, P., Sousa Uva, M., Taggart, D. P., Torracca, L., Valgimigli, M., Wijns, W., Witkowski, A., Kolh, P., & Juni, P. (2014). Revascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysis. BMJ, 348, g3859. doi:10.1136/bmj.g3859.
Valgimigli, M., Sabate, M., Kaiser, C., Brugaletta, S., de la Torre Hernandez, J. M., Galatius, S., Cequier, A., Eberli, F., de Belder, A., Serruys, P. W., & Ferrante, G. (2014). Effects of cobalt-chromium everolimus eluting stents or bare metal stent on fatal and non-fatal cardiovascular events: patient level meta-analysis. BMJ, 349, g6427. doi:10.1136/bmj.g6427.
Palmerini, T., Biondi-Zoccai, G., Della Riva, D., Stettler, C., Sangiorgi, D., D’Ascenzo, F., Kimura, T., Briguori, C., Sabate, M., Kim, H. S., De Waha, A., Kedhi, E., Smits, P. C., Kaiser, C., Sardella, G., Marullo, A., Kirtane, A. J., Leon, M. B., & Stone, G. W. (2012). Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. Lancet, 379(9824), 1393–1402. doi:10.1016/S0140-6736(12)60324-9.
Mauri, L., Kereiakes, D. J., Yeh, R. W., Driscoll-Shempp, P., Cutlip, D. E., Steg, P. G., Normand, S. L., Braunwald, E., Wiviott, S. D., Cohen, D. J., Holmes, D. R., Jr., Krucoff, M. W., Hermiller, J., Dauerman, H. L., Simon, D. I., Kandzari, D. E., Garratt, K. N., Lee, D. P., Pow, T. K., Ver Lee, P., Rinaldi, M. J., Massaro, J. M., & Investigators DS. (2014). Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. The New England Journal of Medicine, 371(23), 2155–2166. doi:10.1056/NEJMoa1409312.
Bonaca, M. P., Bhatt, D. L., Cohen, M., Steg, P. G., Storey, R. F., Jensen, E. C., Magnani, G., Bansilal, S., Fish, M. P., Im, K., Bengtsson, O., Ophuis, T. O., Budaj, A., Theroux, P., Ruda, M., Hamm, C., Goto, S., Spinar, J., Nicolau, J. C., Kiss, R. G., Murphy, S. A., Wiviott, S. D., Held, P., Braunwald, E., Sabatine, M. S., Committee P-TS, & Investigators. (2015). Long-term use of ticagrelor in patients with prior myocardial infarction. The New England Journal of Medicine. doi:10.1056/NEJMoa1500857.
Ando, G., Cortese, B., Frigoli, E., Gagnor, A., Garducci, S., Briguori, C., Rubartelli, P., Calabro, P., Valgimigli, M., & Investigators M. (2015). Acute kidney injury after percutaneous coronary intervention: rationale of the AKI-MATRIX (acute kidney injury-minimizing adverse hemorrhagic events by TRansradial access site and systemic implementation of angioX) sub-study. Catheterization and Cardiovascular Interventions: Official Journal of the Society for Cardiac Angiography & Interventions. doi:10.1002/ccd.25932.
Picchi, A., Limbruno, U., Ando, G., Brugaletta, S., Cortese, B., De Carlo, M., Garcia-Garcia, H. M., Palmieri, C., Regar, E., Rigattieri, S., Sardella, G., Zimarino, M., & Valgimigli, M. (2015). Optical coherence tomography appraisal of residual thrombus burden in patients with ST-segment elevation myocardial infarction undergoing intraprocedural versus post-stenting prolonged bivalirudin infusion. Rationale and design of the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) OCT substudy. EuroIntervention: Journal of EuroPCR in Collaboration With the Working Group on Interventional Cardiology of the European Society of Cardiology, 10(11), 1311–1317. doi:10.4244/EIJY15M02_10.
Valgimigli, M., Gagnor, A., Calabro, P., Frigoli, E., Leonardi, S., Zaro, T., Rubartelli, P., Briguori, C., Ando, G., Repetto, A., Limbruno, U., Cortese, B., Sganzerla, P., Lupi, A., Galli, M., Colangelo, S., Ierna, S., Ausiello, A., Presbitero, P., Sardella, G., Varbella, F., Esposito, G., Santarelli, A., Tresoldi, S., Nazzaro, M., Zingarelli, A., de Cesare, N., Rigattieri, S., Tosi, P., Palmieri, C., Brugaletta, S., Rao, S. V., Heg, D., Rothenbuhler, M., Vranckx, P., Juni, P., & Investigators M. (2015). Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial. Lancet. doi:10.1016/S0140-6736(15)60292-6.
Sciahbasi, A., Calabro, P., Sarandrea, A., Rigattieri, S., Tomassini, F., Sardella, G., Zavalloni, D., Cortese, B., Limbruno, U., Tebaldi, M., Gagnor, A., Rubartelli, P., Zingarelli, A., & Valgimigli, M. (2014). Randomized comparison of operator radiation exposure comparing transradial and transfemoral approach for percutaneous coronary procedures: rationale and design of the minimizing adverse haemorrhagic events by TRansradial access site and systemic implementation of angioX-RAdiation Dose study (RAD-MATRIX). Cardiovascular Revascularization Medicine: Including Molecular Interventions, 15(4), 209–213. doi:10.1016/j.carrev.2014.03.010.
Valgimigli, M., Calabro, P., Cortese, B., Frigoli, E., Garducci, S., Rubartelli, P., Ando, G., Santarelli, A., Galli, M., Garbo, R., Repetto, A., Ierna, S., Briguori, C., Limbruno, U., Violini, R., Gagnor, A., & Investigators M. (2014). Scientific foundation and possible implications for practice of the Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX (MATRIX) trial. Journal of Cardiovascular Translational Research, 7(1), 101–111. doi:10.1007/s12265-013-9537-1.
Verheye, S., Jolicoeur, E. M., Behan, M. W., Pettersson, T., Sainsbury, P., Hill, J., Vrolix, M., Agostoni, P., Engstrom, T., Labinaz, M., de Silva, R., Schwartz, M., Meyten, N., Uren, N. G., Doucet, S., Tanguay, J. F., Lindsay, S., Henry, T. D., White, C. J., Edelman, E. R., & Banai, S. (2015). Efficacy of a device to narrow the coronary sinus in refractory angina. The New England Journal of Medicine, 372(6), 519–527. doi:10.1056/NEJMoa1402556.