Article (Scientific journals)
Drug loading of sutures by supercritical CO2 impregnation: effect of polymer/drug interactions and thermal transitions
Champeau, Mathilde; Thomassin, Jean-Michel; Tassaing, Thierry et al.
2015In Macromolecular Materials and Engineering, 300 (6), p. 596-610
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Keywords :
biomaterial; implant; supercritical carbon dioxide
Abstract :
[en] This paper aims at exploring the scCO2 impregnation of three commonly implanted polymer sutures made of poly-l-lactide (PLLA), poly(ethylene terephthalate) (PET) and polypropylene (PP) with two anti-inflammatory drugs namely ketoprofen and aspirin. For all the investigated polymer/drug systems, the drug loading increases with temperature and pressure. It appears that two main criteria must be fulfilled by the polymer to achieve high drug loading: (i) a good affinity between the polymer and the drug and (ii) a high chain mobility to favor the diffusion of the drug into the matrix. As the investigated PLLA fulfills these two requirements, drug loading up to 32.5% with ketoprofen and 8.1% with aspirin has been achieved.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Champeau, Mathilde;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Thomassin, Jean-Michel ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Tassaing, Thierry;  University of Bordeaux, Institute of Molecular Sciences, France
Jérôme, Christine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Drug loading of sutures by supercritical CO2 impregnation: effect of polymer/drug interactions and thermal transitions
Publication date :
June 2015
Journal title :
Macromolecular Materials and Engineering
ISSN :
1438-7492
eISSN :
1439-2054
Publisher :
Wiley, Weinheim, Germany
Volume :
300
Issue :
6
Pages :
596-610
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
BELSPO - Politique scientifique fédérale [BE]
Conseil Général d'Aquitaine [FR]
The Internatonal Doctoral School IDS-Funmat
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