Article (Scientific journals)
Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines
Habyalimana, Védaste; Mbinze Kindenge, Jérémie; Kalenda Tshilombo, Nicodème et al.
2015In American Journal of Analytical Chemistry, 6, p. 977-994
Peer reviewed
 

Files


Full Text
AJAC_2015120214213538.pdf
Publisher postprint (2.97 MB)
http://dx.doi.org/10.4236/ajac.2015.613093
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Poor Quality Medicines; Antimalarial Medicines; Visual Inspection; Simple and Complex Analytical Tools
Abstract :
[en] Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and analytical tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several analytical techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chemical characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex analytical techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various analytical tools that can be used in detecting and identifying unknown component in poor quality medicines.
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Habyalimana, Védaste ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Mbinze Kindenge, Jérémie;  Université de Kinshasa, Faculté des Sciences Pharmaceutiques, République Démocratique du Congo
Kalenda Tshilombo, Nicodème ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Dispas, Amandine  ;  Université de Liège > Département de pharmacie > Chimie analytique
Yemoa Loconon, Achille;  Université d’Abomey Calavi, Faculté des Sciences de la Santé, Ecole de Pharmacie, Cotonou, Bénin
Sacre, Pierre-Yves  ;  Université de Liège > Département de pharmacie > Chimie analytique
Widart, Joëlle ;  Université de Liège > Département de pharmacie > Département de pharmacie - CIRM
De Tullio, Pascal ;  Université de Liège > Département de pharmacie > Chimie pharmaceutique
Counerotte, Stéphane ;  Université de Liège > Département de pharmacie > Département de pharmacie
Kadima Ntokamunda, Justin-Léonard;  University of Rwanda, School of Medicine and Pharmacy, Butare, Rwanda
Ziemons, Eric  ;  Université de Liège > Département de pharmacie > Département de pharmacie
Hubert, Philippe  ;  Université de Liège > Département de pharmacie > Chimie analytique
Marini Djang'Eing'A, Roland ;  Université de Liège > Département de pharmacie > Chimie analytique
More authors (3 more) Less
Language :
English
Title :
Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines
Publication date :
02 December 2015
Journal title :
American Journal of Analytical Chemistry
ISSN :
2156-8251
eISSN :
2156-8278
Publisher :
Scientific Research Publishing, Irvine, United States - California
Volume :
6
Pages :
977-994
Peer reviewed :
Peer reviewed
Commentary :
http://dx.doi.org/10.4236/ajac.2015.613093
Available on ORBi :
since 26 January 2016

Statistics


Number of views
331 (34 by ULiège)
Number of downloads
251 (16 by ULiège)

OpenCitations
 
3

Bibliography


Similar publications



Contact ORBi