Article (Scientific journals)
Effects of Hormones and Drugs on Cartilage Repair
Franchimont, P.; Bassleer, C.; Henrotin, Yves
1989In Journal of Rheumatology. Supplement, 18, p. 5-9
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Abstract :
[en] When cartilage is attacked, either by an excess of charges or by biochemical agents, its morphological and functional impairment is associated with a local homeostatic reaction; this includes a proliferative response (assessed by 3H-thymidine incorporation) and a stimulation of proteoglycan and type II collagen (II coll) synthesis. This homeostatic reaction may be studied in vitro using tridimensional culture of human chondrocytes. Cartilage clusters are formed after 4 days' culture and chondrocytes multiply for the first 15 days of culture. Furthermore, human cartilage proteoglycans and II coll, assayed by specific radioimmunoassays, are released into the culture medium and constitute the new matrix of the clusters. Moreover, it appears that these human chondrocytes are targets for several hormones capable of stimulating a proliferative response without affecting proteoglycan and II coll synthesis.
Disciplines :
Rheumatology
Author, co-author :
Franchimont, P.
Bassleer, C.
Henrotin, Yves  ;  Université de Liège - ULiège > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Language :
English
Title :
Effects of Hormones and Drugs on Cartilage Repair
Publication date :
August 1989
Journal title :
Journal of Rheumatology. Supplement
ISSN :
0380-0903
Publisher :
Journal of Rheumatology Publishing Co., Canada
Volume :
18
Pages :
5-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2016

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