Article (Scientific journals)
OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis
Kloppenburg, M.; Maheu, E.; Kraus, V. B. et al.
2015In Osteoarthritis and Cartilage, 23 (5), p. 772-86
Peer Reviewed verified by ORBi
 

Files


Full Text
kloppenburg.pdf
Publisher postprint (617.65 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Hand osteoarthritis (OA) is a very frequent disease, but yet understudied. However, a lot of works have been published in the past 10 years, and much has been done to better understand its clinical course and structural progression. Despite this new knowledge, few therapeutic trials have been conducted in hand OA. The last OARSI recommendations for the conduct of clinical trials in hand OA dates back to 2006. The present recommendations aimed at updating previous recommendations, by incorporating new data. The purpose of this expert opinion, consensus driven exercise is to provide evidence-based guidance on the design, execution and analysis of clinical trials in hand OA, where published evidence is available, supplemented by expert opinion, where evidence is lacking, to perform clinical trials in hand OA, both for symptom and for structure-modification. They indicate core outcome measurement sets for studies in hand OA, and list the methods and instruments that should be used to measure symptoms or structure. For both symptom- and structure-modification, at least pain, physical function, patient global assessment, HR-QoL, joint activity and hand strength should be assessed. In addition, for structure-modification trials, structural progression should be measured by radiographic changes. We also provide a research agenda listing many unsolved issues that seem to most urgently need to be addressed from the perspective of performing "good" clinical trials in hand OA. These updated OARSI recommendations should allow for better standardizing the conduct of clinical trials in hand OA in the next future.
Disciplines :
Rheumatology
Author, co-author :
Kloppenburg, M.
Maheu, E.
Kraus, V. B.
Cicuttini, F.
Doherty, M.
Dreiser, R. L.
Henrotin, Yves  ;  Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)
Jiang, G. L.
Mandl, L.
Martel-Pelletier, J.
Nelson, A. E.
Neogi, T.
Pelletier, J. P.
Punzi, L.
Ramonda, R.
Simon, L. S.
Wang, S.
Group, Oarsi Hand Clinical Trial Recommendations Work
More authors (8 more) Less
Language :
English
Title :
OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis
Publication date :
2015
Journal title :
Osteoarthritis and Cartilage
ISSN :
1063-4584
eISSN :
1522-9653
Publisher :
Elsevier, United Kingdom
Volume :
23
Issue :
5
Pages :
772-86
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 January 2016

Statistics


Number of views
40 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
82
Scopus citations®
without self-citations
59
OpenCitations
 
74

Bibliography


Similar publications



Contact ORBi