Article (Scientific journals)
Whole-body 18FDG positron emission tomography in the staging of non-small cell lung cancer.
Bury, Thierry; Dowlati, A.; Paulus, Patrick et al.
1997In European Respiratory Journal, 10 (11), p. 2529-34
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Keywords :
Carcinoma, Non-Small-Cell Lung/pathology/radionuclide imaging; Female; Fluorine Radioisotopes/diagnostic use; Fluorodeoxyglucose F18/diagnostic use; Lung Neoplasms/pathology/radionuclide imaging; Lymphatic Metastasis; Neoplasm Staging; Non-small cell lung cancer; Positron emission tomography; Presurgical staging; Predictive Value of Tests; Radiopharmaceuticals/diagnostic use; Tomography, Emission-Computed
Abstract :
[en] Despite advances in morphological imaging, some patients with lung cancer are found to have nonresectable disease at surgery or die of recurrence within yr of surgery. We performed a prospective study in 109 patients to compare the accuracy of whole-body positron emission tomography (PET) using fluorine-18 deoxyglucose (18FDG) and conventional imaging (CI) methods for the staging of non-small cell lung cancer (NSCLC). When CI or PET study suggested metastatic disease, confirmation was obtained by biopsy or follow-up information. As compared to CI, 18FDG-PET correctly changed the N stage in 22 patients (33%) and the M stage in 15 patients (14%). For the detection of distant metastases, PET study showed five false-positive sites and no false-negative cases. Currently, the accuracy of PET in the detection of M stage is 96%. Our study shows that visual interpretation of whole-body fluorine-18 deoxyglucose-positron emission tomography images can improve the diagnostic accuracy in the staging of non-small cell lung cancer. Further experience is needed to establish if metabolic imaging would be a cost-effective tool in the future management of lung cancer.
Disciplines :
Oncology
Radiology, nuclear medicine & imaging
Author, co-author :
Bury, Thierry ;  Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique
Dowlati, A.
Paulus, Patrick
Corhay, Jean-Louis ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Ghaye, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > Imagerie médicale
Radermecker, Maurice ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Rigo, Pierre ;  Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
Language :
English
Title :
Whole-body 18FDG positron emission tomography in the staging of non-small cell lung cancer.
Publication date :
November 1997
Journal title :
European Respiratory Journal
ISSN :
0903-1936
eISSN :
1399-3003
Publisher :
European Respiratory Society, Lausanne, Switzerland
Volume :
10
Issue :
11
Pages :
2529-34
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 January 2010

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